CTLA4 (NM_005214) Human Recombinant Protein

CAT#: TP723874

Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1



  View other "CTLA4" proteins (9)

Need it in bulk or customized?
Get a free quote

CNY 2,590.00


货期*
详询

规格
    • 10 ug

Product images

经常一起买 (1)
CTLA4 mouse monoclonal antibody,clone OTI1G10
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
Human CTLA-4, the region of Ala37-Phe162, from gene Accession# NM_005214
Tag Fc chimera
Predicted MW 39.9 kDa
Concentration lot specific
Purity >95%, as determined by Coomassie stained SDS-PAGE
Buffer 1 x PBS
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Bioactivity Recombinant human CTLA-4 inhibits the production of IL-2 induced by 0.5 μg/mL of CD80 on Jurkat cells in a dose-dependent manner. The ED50 for this effect 50 is 4 - 24 ng/mL.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Reference Data
RefSeq NP_005205
Locus ID 1493
UniProt ID P16410
Refseq Size 1997
Cytogenetics 2q33.2
Refseq ORF 669
Synonyms ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
Summary This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Other Versions

Customer Reviews 
Loading...