Fibronectin (FN1) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Glu5-Thr95
Tag	N-6His&Avi
Buffer	Supplied as a 0.2 um filtered solution of 50mM Tris, 150mM NaCl, pH7.2.
Note	Recombinant Human Fibronectin is produced by our E.coli expression system and the target gene encoding Glu5-Thr95 is expressed with a 6His, Avi tag at the N-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	2335
UniProt ID	P02751
Summary	Fibronectin is a glycoprotein of the extracellular matrix that binds integrins. It binds to extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans. Multiple isoforms result from alternative mRNA splicing of the ED-A, ED-B, and III-CS regions, and post-translational modification. Fibronectin is critical for cell adhesion, growth, migration, and differentiation, as well as wound healing and embryonic development. Altered fibronectin expression, degradation, and organization are associated with pathologies, including cancer and fibrosis. Fragmentation of pericellular fibronectin and increased production by peritumoral stroma are early signs of malignant transformation in solid human tumors. Further investigations are encouraged to explore the potential importance of fibronectin production and breakdown during cancer progression.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.