Il1rn Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Arg27-Gln178
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4
Note	Recombinant Mouse Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg27-Gln178 is expressed.
Stability	12 months from date of despatch
Reference Data
Locus ID	16181
UniProt ID	P25085
Summary	Interleukin-1 receptor antagonist protein (IL-1RA), also known as IL1 inhibitor, is a member of the interleukin 1 cytokine family. IL-1RA inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and is involved in a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse IL-1RA protein shares 26% and 19% identity with its homologs IL-1 beta and IL-1 alpha, respectively. IL-1RA can suppress the activity of interleukin-1 by binding to receptor IL1R1 and averting its association with the coreceptor IL1RAP for signaling. In recent studies, recombinant human IL-1RA proteins are used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.

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