CD16 (FCGR3A) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gly17-Gln208
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4
Note	Recombinant Human Fc gamma RIIIA (V176) is produced by our Mammalian expression system and the target gene encoding Gly17-Gln208 is expressed with a 6His tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	2214
UniProt ID	P08637
Summary	Receptors for the Fc region of immunoglobin gamma (FCGR) are divided into three classes and FCGR3A is a multifunctional, low/intermediate affinity receptor. In humans, FCGR3A is expressed as two distinct forms (FCGR3A and FCGR3B) that are encoded by two different but highly homologous genes in a cell type-specific manner. FCGR3B is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, while FCGR3A is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FCGR3A receptor plays roles in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FCGR3A has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses.

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