Cynomolgus Recombinant Protein

Specifications

Product Data
Species	Cynomolgus
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ser25-Tyr392
Tag	C-6His
Buffer	Supplied as a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Cynomolgus ROR1 is produced by our Mammalian expression system and the target gene encoding Ser25-Tyr392 is expressed with a 6His tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Summary	ROR1, also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a type I transmembrane protein that belongs to the ROR family within receptor tyrosine kinases superfamily. ROR1 is expressed at high levels during early embryonic development. Isoform Short is highly expressed in fetal and adult CNS and various human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 is found to play important roles in developmental morphogenesis by acting as receptors or co-receptors to regulate Wnt5a-induced signaling. ROR1 could interact with casein kinase 1 epsilon to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein, which links to enhanced tumor-cell growth.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.