Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ala2-Leu441
Tag	N-His
Buffer	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Note	Recombinant Human Tau protein is produced by our Mammalian expression system and the target gene encoding Ala2-Leu441 is expressed with a 6His tag at the N-terminus.
Stability	12 months from date of despatch
Reference Data
Summary	Tau is a microtubule-associated protein expressed primarily in neurons. Tau promotes the assembly and stabilization of microtubules along with other MAP proteins. It is thought that other proteins can compensate for loss of Tau protein function as Tau knockout mice are viable and show no signs of neurodegeneration. There are multiple isoforms of Tau created by alternative splicing of exons 2, 3, and 10. When tau proteins are defective and no longer stabilize microtubules properly, they can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

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