RBM20 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) E931-L1227
Tag	C-His
Buffer	Supplied as a 0.2 um filtered solution of 500mM PBS, 300mM NaCl, 10%Glycerol, pH7.4
Note	MADE TO ORDER | Recombinant Human RNA-binding protein 20/RBM20 is produced by E.coli expression system and the target gene encoding E931-L1227 is expressed with a His tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	282996
UniProt ID	Q5T481
Summary	RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH. Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts. RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles. RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts. Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes.

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