PD-L1 (CD274) Human Recombinant Protein
CAT#: TP727742
Recombinant Human Programmed Cell Death 1 Ligand 1 (C-Fc-Avi)
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CNY 2,380.00
货期*
2周
规格
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经常一起买 (1)
PD-L1 / CD274 mouse monoclonal antibody, clone OTI2C7 (formerly 2C7)
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Species | Human |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Phe19-Thr239
|
Tag | C-Fc&AVI |
Buffer | Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
Note | Biotinylated Recombinant Human Programmed Cell Death 1 Ligand 1 is produced by our Mammalian expression system and the target gene encoding Phe19-Thr239 is expressed with a Fc, Avi tag at the C-terminus. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 29126 |
UniProt ID | Q9NZQ7 |
Summary | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. |
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