CD3E Cynomolgus Recombinant Protein

Specifications

Product Data
Species	Cynomolgus
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gln22-Asp117
Tag	C-Fc
Buffer	Lyophilized from a 0.2 um filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH7.5.
Note	Recombinant Cynomolgus monkey T-cell surface glycoprotein CD3 epsilon chain is produced by our Mammalian expression system and the target gene encoding Gln22-Asp117 is expressed with a Fc tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	102133065
UniProt ID	Q95LI5
Summary	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

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