HSD17B1 (NM_000413) Human Recombinant Protein

CAT#: TP762706

Purified recombinant protein of Human hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1), 2Ala-End, with N-terminal His tag, expressed in E.coli, 50ug



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CNY 2,480.00


货期*
现货

规格
    • 50 ug

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经常一起买 (1)
Rabbit Polyclonal Anti-HSD17B1 Antibody
    • 100 ul

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region (2Ala-End) of HSD17B1
Tag N-His
Predicted MW 37.1 kDa
Concentration >0.05 ug/ul as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, 150mM NaCl, 10% glycerol, pH8.0, 1% SKL
Storage Store at -80°C after receiving vials.
Stability Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000404
Locus ID 3292
UniProt ID P14061
Refseq Size 2248
Cytogenetics 17q21.2
Refseq ORF 984
Synonyms 17-beta-HSD; 20-alpha-HSD; E2DH; EDH17B2; EDHB17; HSD17; SDR28C1
Summary This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Protein Families Druggable Genome
Protein Pathways Androgen and estrogen metabolism, Metabolic pathways
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