Antibodies

Antibodies

Primary Antibodies

ALKALINE PHOSPHATASE

DPP8

EXOC7

FATTY ACID SYNTHASE

MPP2

PCBP2

TBX6

UNC13B

A RAF

ACAD8

ACT

ACTIN

ACTIVIN RECEPTOR TYPE IIA

ADAMTSL2

ADCK1

AK3L1

AKT1

ALPHA 2 ANTIPLASMIN

ALPHA GLUCOSIDASE II

ALPHA INTERNEXIN

AMINOACYLASE 1

AMPHIPHYSIN

AMPK GAMMA 3

AMYLOID PRECURSOR PROTEIN

ANNEXIN A1

AP1M1

AP2M1

AP4M1

APBB3

ARA9

ARF5

ARPC1A

ASB4

ASPA

ASPARTYL AMINOPEPTIDASE

ATAXIN 3

ATIC

ATP6V0A4

ATP6V1C2

BAG5

BBS7

BEN DOMAIN CONTAINING PROTEIN 5

BLNK

BMP10

BPGM

BXDC1

C-JUN

C-MYC

C2

C2ORF47

CALBINDIN

CALPAIN 5

CALRETININ

CAPZB

CASPASE 9

CD26

CD41

CDA11

CDC26

CDC45L

CDK3

CENTAURIN ALPHA 1

CIP29

CKAP1

CLIC3

CMAS

CNGA2

COATOMER SUBUNIT DELTA

COPROPORPHYRINOGEN OXIDASE

CORO1B

COX5B

CREB1

CRTAP

CRYBA4

CTNNAL1

CYCLIN T2

DAP5

DCTN1

DDAH1

DELTEX

DMC1

DNA POLYMERASE DELTA P50

DNA POLYMERASE EPSILON

DNAJB11

DOK3

DRAK1

EEF1AKMT4

EIF3K

ELF4

ENTPD6

EPOXIDE HYDROLASE

ERK2

ETFB

ETV6

EXT2

FACTOR IX

FACTOR XIIIA

FASCIN

FBXL12

FBXO2

Human

Mouse

Rat

Monkey

Dog

Bovine

Canine

Porcine

Cow)

Human (Expected from sequence similarity: Mouse

Rabbit

Chicken

Pig

Human (Predicted: Mouse

Cynomolgus

Hamster

SARS-CoV-2

Zebrafish

Bovine)

Primate

Dog)

Xenopus

Rat)

Mammalian

Sheep

Feline

Pig)

Guinea Pig

Gorilla

Equine

Chimpanzee

Bat

Cow

Other (Wide Range)

Drosophila

Goat

Influenza A Virus

Escherichia coli

Mouse (Expected from sequence similarity: Rat

Gibbon

Macaque

Rabbit)

X. tropicalis)

Mouse (Predicted: Rat

Horse

All Species

Human (Predicted: Monkey)

Mouse (Expected from sequence similarity: Human

Human (Predicted: Rat

Human (Predicted: Mouse)

Human (Expected from sequence similarity: Dog

Yeast

Rat (Expected from sequence similarity: Dog

Rhesus Monkey)

Rhesus Monkey

Human (Expected from sequence similarity: Dog)

Mouse)

Rat (Expected from sequence similarity: Human

C. elegans

Xenopus)

HIV

Human (Predicted: Monkey

Human (Predicted: Bovine)

Hepatitis B Virus

Vertebrates

Horse)

Fish

Human (Expected from sequence similarity: Mouse)

Human (Predicted: Bovine

Human (Expected from sequence similarity: Rat

Chicken)

Human Immunodeficiency Virus 1

Mouse (Predicted: Bovine)

SARS-CoV

Mouse (Expected from sequence similarity: Rat)

Borrelia burgdorferi

Broad

Hamster)

Hepatitis C Virus

Mouse (Predicted: Rat)

Bakers Yeast

Human (Expected from sequence similarity: Cow)

Human (Predicted: Rhesus Monkey)

Orang-Utan

Rat (Expected from sequence similarity: Mouse

Bacteria

Monkey)

Baboon

Rat (Expected from sequence similarity: Dog)

Human (Predicted: Pig

Virus

Zebrafish)

Frog

Helicobacter pylori

His tag

Human (Does not react with: Mouse)

Myc tag

V5 tag

Amphibian

Cytomegalovirus

Human (Predicted: Chimpanzee)

Human (Predicted: Rat)

Influenza B Virus

Mouse (Predicted: Chicken

Respiratory Syncytial Virus

Mouse (Predicted: Rhesus Monkey)

Adeno-Associated Virus 2

Saccharomyces cerevisiae

Staphylococcus aureus

Ape

Arabidopsis

GST tag

Human (Predicted: Bat

Pig (Expected from sequence similarity: Dog

X. tropicalis

Bacillus sp.

Human (Predicted: Dog

Mouse (Predicted: Pig

Chlamydia trachomatis

Epstein Barr Virus

Mouse (Expected from sequence similarity: Dog

Opossum

Rat (Expected from sequence similarity: Mouse)

West Nile Virus

Canis

DDK (FLAG tag): DYKDDDDK

Mink

Streptococcus Pyogenes

Adeno-Associated Virus 5

Gibbon (Predicted: Monkey

Gibbon (Predicted: Monkey)

Guinea Pig)

Human (Expected from sequence similarity: Pig

Human (Predicted: Chicken

Human (Predicted: Pig)

Mouse (Predicted: Chimpanzee)

Mycobacterium tuberculosis

RFP

Adeno-Associated Virus

Duck

Mouse (Predicted: Bovine

Pollen

Rat (Expected from sequence similarity: Cow)

rRFP

Clostridium botulinum

Clostridium difficile

Expected from sequence similarity: Human

Ferret

Human (Expected from sequence similarity: Rat)

Human Alphaherpesvirus 1

Human Alphaherpesvirus 2

Plant

Rat (Predicted: Mouse

Streptococcus sp.

mCherry

Adeno-Associated Virus 8

African clawed frog

Aspergillus

Birds

Geodia cydonium

Human (Predicted: Chimpanzee

Human (Predicted: Dog)

Human (Predicted: Xenopus)

Insect

mOrange

Candida

Enterobacter

Horse (Predicted: Monkey

Human (Expected from sequence similarity: Pig)

Marmoset

Salmonella species

Schistosoma japonicum

A. victoria

Avian

DsRed-Monomer

E2-Crimson

Gerbil

HA tag

Horse (Predicted: Mouse

Human (Predicted: Bat)

Human (Predicted: Xenopus

Mouse (Expected from sequence similarity: Human)

Mycoplasma pneumoniae

Penicillium

Rat (Expected from sequence similarity: Human)

Rat (Expected from sequence similarity: Pig

Rotavirus

Timer

Turkey

eGFP

tdTomato

Aspergillus niger

Broad Range

Chimpanzee)

Chlamydia pneumoniae

Deer

Dendra2

Feline Leukemia Virus

Gibbon (Predicted: Mouse

Hepatitis A Virus

Human (Predicted: Chicken)

Human (Predicted: Cow)

Human (Predicted: Rabbit)

Human Herpesvirus 6

Mouse (Expected from sequence similarity: Dog)

Mouse (Predicted: Chimpanzee

Mouse (Predicted: Dog

Mouse (Predicted: Monkey)

Mustelid

Non-human primates

Orang-Utan (Predicted: Monkey

Photinus pyralis

Pig (Expected from sequence similarity: Dog)

Rabies Lyssavirus

Snake

Trichomonas vaginalis

mBanana

mGFP

mPlum

mStrawberry

mYFP

AAVPHP.B

Adeno-Associated Virus 1

Adeno-Associated Virus 3

Alcaligenes

C. elegans)

Campylobacter jejuni

Clostridium tetanis

Ebola virus

GFP tag

Giardia lamblia

Horse (Predicted: Bovine

Horseradish Peroxidase

Huaiyangshan-Virus

Human (Predicted: Cow

Human (Predicted: Hamster)

Human (Predicted: Rabbit

Human Immunodeficiency Virus 2

Human Parainfluenza Viruses 1

Kangaroo

Leuconostoc

Maize

Mouse (Predicted: Rabbit

Murine

Neisseria gonorrhoeae

Orang-Utan (Predicted: Monkey)

Pig (Expected from sequence similarity: Cow)

Pig (Expected from sequence similarity: Rat

Quail

Rat (Predicted: Bovine

Rift Valley Fever Virus

Sheep)

Streptococcus pneumoniae

Tomato

Toxoplasma gondii

Yellow Fever Virus

mBFP

mCherry tag

mKate

mRFP

tYFP

AcGFP1

Adeno-Associated Virus 6

Adeno-Associated Virus 9

AmCyan1

AsRed2

Bacillus Anthracis

Bacillus amyloliquefacies

Beluga

Biotin

Bordetella pertussis

BrdU

Burkholderia

Carica papaya

Carp

Chlamydia psittaci

Clostridium histolyticum

Cryptosporidium parvum

Cucurbita

Dengue Virus Types 2

DsRed-Express2

DsRed2

FITC

Feline Immunodeficiency Virus

Fruit fly

GFP

Hamster (Predicted: Monkey

Hantaan Virus

Horse (Predicted: Bat

Horse (Predicted: Monkey)

Human (Expected from sequence similarity: Cow

Human (Expected from sequence similarity: Feline

Human (Predicted: Zebrafish

Human Parainfluenza Viruses 3

Human coronavirus HKU1

Human coronavirus OC43

Jack Bean

Kaposi-Sarkom-Herpesvirus

KillerRed

Lactococcus lacti

Legionella pneumophila

Leishmania donovani

Mouse (Predicted: Human

Mouse (Predicted: Monkey

Mouse (Predicted: Pig)

PS-CFP2

Photobacterium fischerii

Pig (Expected from sequence similarity: Human

Plasmodium falciparum

Protozoa

Puumala Virus

Rat (Expected from sequence similarity: Cow

Rat (Predicted: Bovine)

Rat (Predicted: Mouse)

Reptiles

Rhizopus

Sin Nombre orthohantavirus

Strep-tag II

Tobacco

Treponema pallidum

Ustilago maydis

Vaccinia virus

Vibrio cholerae

Zika-Virus

ZsGreen1

ZsYellow1

eCFP

eRFP

mCFP

mOrange2

mRaspberry

tGFP

5-FAM

Adeno-Associated Virus 14

Adeno-Associated Virus 31

Adeno-Associated Virus 4

Adeno-Associated Virus 40

Adeno-Associated Virus 41

Andes orthohantavirus

Arabidopsis thaliana

Bacillus species

Bacterial

Bacteriophage P1

Borrelia afzelii

Borrelia burgdorferi B31

Bovine Adenovirus 1

Bovine Coronavirus

Brevibacterium

Brugia malayi

Burkholderia cenocepacia

Canavalia ensiformis (Jack Bean)

Canine Adenovirus 1

Canine Distemper Virus

Clostridium kluyveri

Clostridium tetani

Coral

Corynebacterium diphtheriae

Cow (Expected from sequence similarity: Mouse

Cucumber Necrosis Virus

Dengue Virus Types 1

Dengue Virus Types 3

Dengue Virus Types 4

Dengue virus

Digoxin

Dog (Expected from sequence similarity: Human

Donkey

Fungi

Gibbon (Predicted: Bat

Gibbon (Predicted: Dog

Golden Syrian Hamster

Gram Positive Bacteria

HBA1c

HPV11

Haemophilus influenzae

Hamster (Predicted: Bat

Heartland Virus

Horse (Predicted: Bat)

Horse (Predicted: Dog

Horse (Predicted: Rat

Horse (Predicted: Xenopus)

Horsereddish

Human (Predicted: Rhesus Monkey

Human (Predicted: X. tropicalis)

Human Papilloma Virus 16

Human Parainfluenza Viruses 2

Human coronavirus 229E

IdU

Invertebrate

Japanese Encephalitis Virus

Klebsiella pneumoniae

Lactobacillus leichmannii

Leuconostoc mesenteroides

Lima Bean

M13 Bacteriophage

MAP tag

MBP tag

MERS-CoV

Measles Virus

Micrococcus luteus

Mouse (Expected from sequence similarity: Cow)

Mouse (Predicted: Chicken)

Mouse (Predicted: Dog)

Mouse (Predicted: Feline

Mouse (Predicted: Human)

Mouse (Predicted: Xenopus

Mouse (Predicted: Zebrafish

Mouse (Predicted: Zebrafish)

Mouse (weak)

Mycobacteria

Myrothecium

Neisseria meningitidis

Norovirus

Orang-Utan (Predicted: Mouse

P. testosteroni

Pigeon

Plasmodium berghei

Pseudomonas aeruginosa

Rat (Expected from sequence similarity: Pig)

Rat (Predicted: Pig)

Rhodopseudomonas spheroides

Ricinus communis

Roseburia hominis

Rubella Virus

Salmonella Typhimurium

Salmonella enteritidis

Soy Bean

Species independent

Squirrel

St. Louis Encephalitis Virus

Streptomyces avidinii

Sweet Potato

Yersinia enterocolitica

tRFP

var.

Adeno-Associated Virus 10

Adeno-Associated Virus 11

Adeno-Associated Virus 13

Adeno-Associated Virus 18

Adeno-Associated Virus 20

Adeno-Associated Virus 26

Adeno-Associated Virus 7

Adeno-Associated Virus 7a

Algal

Alligator

Arthrobacter globiformis

Athrobacterium ureafaciens

Bacillus cereus

Bacillus subtilis

Bear

Beta Galactosidase [E.coli]

Bison

Bonito

Bovine (Does not react with: Rat)

C. elegans (Does not react with: Human

Campylobacter venerealis

Candida species

Canine Coronavirus

Cellulomonas

Chicken (weak)

Chinese Hamster

Chlamydomonas

CldU

Clostridium chauvoei

Clostridium novyi

Clostridium perfingens

Clostridium septicum

Clostridium sordellii

Cod

Corynebacterium sp

Cow (Does not react with: Mouse)

Cow (Expected from sequence similarity: Dog)

Coxsackievirus 16

DDK

DDK (FLAG) tag

Does not react with: Human

Dog (Expected from sequence similarity: Mouse

Dog (Expected from sequence similarity: Rat

Dogfish

Drosophila (weak)

Drosophila melanogaster

Drosophila)

Edwardsiella tarda

Enterobacter cloacae

Enterobacter cloacea

Enterococcus species

Enterovirus 71

Eukaryote

Feline Calicivirus

Feline Coronavirus

Feline Herpes Virus1

Feline Infectious Peritonitis Virus

Feline)

Fungus

Fusion proteins containing the GST Tag

Fusion proteins containing the HA Tag

Fusion proteins containing the HIS Tag

GFP transfected cells or Pure GFP protein

Gibbon (Predicted: Bovine

Gibbon (Predicted: Hamster)

Gibbon (Predicted: Mouse)

Gibbon (Predicted: Rabbit)

Gibbon (Predicted: Rat

Gram Negative Bacteria

Guinea Pig (Expected from sequence similarity: Dog

Guinea Pig (Predicted: Bat

Guinea Pig (Predicted: Bat)

Guinea Pig (Predicted: Hamster)

Guinea Pig (Predicted: Mouse

HA Tag

Hagfish

Hamster (Predicted: Bovine)

Hamster (Predicted: Dog

Hamster (Predicted: Mouse

Hamster (Predicted: Mouse)

Hamster (Predicted: Rabbit)

Hamster (Predicted: Rat

Hesperocyparis arizonica

Horse (Predicted: Bovine)

Horse (Predicted: Hamster)

Horse (Predicted: Pig)

Horse (Predicted: Rabbit

Horse (Predicted: Xenopus

Human (Does not react with: Mouse

Human (Expected from sequence similarity: Rabbit)

Human (Predicted: Feline

Human (Predicted: Goat

Human (Predicted: Guinea Pig

Human (Predicted: Hamster

Human (Predicted: Horse

Human (Predicted: Sheep

Human (Predicted: Yeast

Human (Predicted: Zebrafish)

Human (weak)

Human Astrovirus

Human IgA

Human IgA1

Human IgA2

Human IgD

Human IgE

Human IgG1

Human IgG3

Human IgM

Human Papilloma Virus 1

Human Papilloma Virus 18

Human Papilloma Virus 2

Human Papilloma Virus 3

Human coronavirus NL63

Human gamma heavy chain

Human kappa light chain

Human lambda light chain

Hydra

Kaposi's Sarcoma-associated herpesvirus

La Crosse encephalitis virus

Lamprey

Leptospira biflexa

Listeria monocytogenes

Medaka fish)

Microbial

Monkey (Does not react with: Mouse)

Monkey (Predicted: Bat

Monkey (Predicted: Dog

Monkey (Predicted: Horse)

Monkey (Predicted: Mouse

Monkey (Predicted: Rat

Mouse (Does not react with: Human)

Mouse (Does not react with: Rabbit)

Mouse (Does not react with: Rat)

Mouse (Expected from sequence similarity: Bovine)

Mouse (Expected from sequence similarity: Cow

Mouse (Predicted: Cow

Mouse (Predicted: Feline)

Mouse (Predicted: Hamster)

Mouse (Predicted: Horse

Mouse (Predicted: Rabbit)

Mouse (Predicted: Sheep

Mouse Ig kappa light chain

Mouse IgG gamma

Mouse IgG1

Mouse IgG2a kappa

Mouse IgG2b

Mouse IgM lambda light chain

Mouse IgM mu-chain

Mus musculus

Myc Tag

Myc and DDK (FLAG) tags

Mycobacterium avium

Mycobacterium smegmatis

Mycoplasma bovis

Mycoplasma hominis

Myrothecium verrucaria

Nebraska Calf Diarrhoea Virus

Newcastle Disease Virus

Nicotiana

Orang-Utan (Does not react with: Mouse)

Orang-Utan (Predicted: Bat

Orang-Utan (Predicted: Bovine

Orang-Utan (Predicted: Dog

Orang-Utan (Predicted: Dog)

Orang-Utan (Predicted: Hamster

Orang-Utan (Predicted: Horse)

Orang-Utan (Predicted: Rat

Orang-Utan (Predicted: Zebrafish)

Paramecium Bursaria Chlorella Virus 1

Parvovirus B19

Pig (Expected from sequence similarity: Feline

Pig (Predicted: Bovine

Plasmodium knowlesi

Porcine (Does not react with: Mouse)

Potoroo

Predicted: Human

Primate (Does not react with: Mouse)

Primate)

Proteus species

Pseudomonas fluorescens

Pufferfish

RFP tag

Rabbit (Does not react with: Primate)

Rabbit (Expected from sequence similarity: Dog

Rabbit (Expected from sequence similarity: Pig

Rabbit IgG Fab

Rabbit IgG Fc

Rat (Does not react with: Human

Rat (Does not react with: Human)

Rat (Does not react with: Primate)

Rat (Expected from sequence similarity: Horse)

Rat (Predicted: Chimpanzee)

Rat (Predicted: Human

Rat (Predicted: Monkey

Rat (Predicted: Rabbit)

Rat.
(not applicable to mouse tissue)

Rhizopus Arrhizus

Rice yellow mottle virus

Salmonella paratyphi

Salmonella typhi

Salmonid

Schistosoma mansoni

Sea Urchin

Seoul Virus

Shigella boydii

Shigella dysenteriae

Shigella flexneri

Shigella sonnei

Silk Worm

SimianIVE

Specific for blue colour used in protein MW markers

Spinach

Staphylococcus epidermidis

Streptococcus

Streptococcus sobrims

Streptomyces

Streptomyces chromofuscus

Streptomyces griseus

Streptomyces species

Streptomyces tsukubaensis

T7 tag

Tadpole

Tdtomato

Tickborne encephalitis virus

Tobacco hornworm

Transmissable Gastroenteritis Virus

Tree Shrew

Trichinella spiralis

Trichomonas foetus

Triticum aestivum

Trout

Trypanosoma brucei

Trypanosoma cruzi

Tuna

VSV-G tag

Venus tag

Whale

White Fly

Widely Range

Wolffish

Xenopus (weak)

YFP tag

Yeast (Does not react with: Xenopus)

Yersinia pestis

Zea mays

Zebrafish (Predicted: Bovine)

tdTomato tag

WB

IHC

IF

FC

IP

Dot

Rabbit

Mouse

Unconjugated

Phospho-specific

IgG

Ig

IgG1

IgG1, kappa

Polyclonal

Monoclonal

Druggable Genome

Transmembrane

Transcription Factors

Protease

Secreted Protein

Protein Kinase

Stem cell - Pluripotency

ES Cell Differentiation/IPS

Phosphatase

GPCR

Embryonic stem cells

Ion Channels: Other

Nuclear Hormone Receptor

Stem cell relevant signaling - JAK/STAT signaling pathway

Stem cell relevant signaling - TGFb/BMP signaling pathway

Cancer stem cells

Induced pluripotent stem cells

Ion Channels: Cyclic nucleotide gated

Ion Channels: Cys-loop Receptors

Stem cell relevant signaling - Wnt Signaling pathway

Metabolic pathways

Pathways in cancer

Insulin signaling pathway

MAPK signaling pathway

Colorectal cancer

Progesterone-mediated oocyte maturation

Purine metabolism

Cell cycle

Focal adhesion

Regulation of actin cytoskeleton

Wnt signaling pathway

Alzheimer's disease

Amino sugar and nucleotide sugar metabolism

B cell receptor signaling pathway

Endometrial cancer

ErbB signaling pathway

Fc gamma R-mediated phagocytosis

Huntington's disease

Pancreatic cancer

Prostate cancer

Small cell lung cancer

T cell receptor signaling pathway

Acute myeloid leukemia

Chemokine signaling pathway

Chronic myeloid leukemia

Fructose and mannose metabolism

Glycolysis / Gluconeogenesis

Melanogenesis

Neurotrophin signaling pathway

Non-small cell lung cancer

Renal cell carcinoma

TGF-beta signaling pathway

Adherens junction

Bladder cancer

Complement and coagulation cascades

DNA replication

Endocytosis

Fc epsilon RI signaling pathway

Glioma

GnRH signaling pathway

Jak-STAT signaling pathway

Melanoma

Natural killer cell mediated cytotoxicity

Oocyte meiosis

Oxidative phosphorylation

Pyrimidine metabolism

Spliceosome

Toll-like receptor signaling pathway

VEGF signaling pathway

Vascular smooth muscle contraction

mTOR signaling pathway

Apoptosis

Calcium signaling pathway

Cytokine-cytokine receptor interaction

Dilated cardiomyopathy

Epithelial cell signaling in Helicobacter pylori infection

Glycine

Homologous recombination

Hypertrophic cardiomyopathy (HCM)

Inositol phosphate metabolism

Leukocyte transendothelial migration

Long-term depression

Long-term potentiation

Lysosome

Neuroactive ligand-receptor interaction

Nucleotide excision repair

One carbon pool by folate

Pentose phosphate pathway

Proteasome

Systemic lupus erythematosus

Ubiquitin mediated proteolysis

Valine

Vibrio cholerae infection

serine and threonine metabolism

Adipocytokine signaling pathway

Antigen processing and presentation

Arginine and proline metabolism

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Basal cell carcinoma

Base excision repair

Cell adhesion molecules (CAMs)

Dorso-ventral axis formation

ECM-receptor interaction

Fatty acid biosynthesis

Folate biosynthesis

Galactose metabolism

Gap junction

Glutathione metabolism

Glycerolipid metabolism

Hedgehog signaling pathway

Hematopoietic cell lineage

Histidine metabolism

Mismatch repair

Notch signaling pathway

O-Glycan biosynthesis

Parkinson's disease

Phosphatidylinositol signaling system

Primary immunodeficiency

Prion diseases

SNARE interactions in vesicular transport

Taste transduction

Thyroid cancer

Type II diabetes mellitus

Viral myocarditis

leucine and isoleucine degradation

Alanine

Aminoacyl-tRNA biosynthesis

Amyotrophic lateral sclerosis (ALS)

Axon guidance

Cardiac muscle contraction

Circadian rhythm - mammal

Drug metabolism - cytochrome P450

Glycosphingolipid biosynthesis - ganglio series

Glycosphingolipid biosynthesis - globo series

Glyoxylate and dicarboxylate metabolism

Heparan sulfate biosynthesis

Keratan sulfate biosynthesis

Lysine degradation

Metabolism of xenobiotics by cytochrome P450

Methane metabolism

N-Glycan biosynthesis

NOD-like receptor signaling pathway

Non-homologous end-joining

Pathogenic Escherichia coli infection

Porphyrin and chlorophyll metabolism

Propanoate metabolism

RNA polymerase

Riboflavin metabolism

Ribosome

Sphingolipid metabolism

Starch and sucrose metabolism

Sulfur metabolism

Terpenoid backbone biosynthesis

Tight junction

Tryptophan metabolism

aspartate and glutamate metabolism

leucine and isoleucine biosynthesis

p53 signaling pathway

2

Yes