Over-expression Lysates

Proteins

Over-expression Lysates

Human

NME2

POLR1C

CMPK1

DTYMK

DUT

INOSINE TRIPHOSPHATE PYROPHOSPHATASE

NM23A

P53R2

RRM2

UCK

UCKL1

AK3

DCK

DHODH

DIHYDROPYRIMIDINASE

DPYD

NME4

NME5

NME6

NUCLEOSIDE DIPHOSPHATE KINASE 7

NUCLEOSIDE PHOSPHORYLASE

POLD1

POLR2C

PRIM1

RRM1

THYMIDINE KINASE 1

THYMIDINE KINASE 2

THYMIDINE PHOSPHORYLASE

THYMIDYLATE SYNTHASE

UCK2

UMPS

UPRT

WB

HEK293T

C-Myc/DDK

WB

Druggable Genome

Transcription Factors

Transmembrane

Stem cell - Pluripotency

Secreted Protein

ES Cell Differentiation/IPS

Metabolic pathways

Pathways in cancer

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Neuroactive ligand-receptor interaction

Focal adhesion

Regulation of actin cytoskeleton

Chemokine signaling pathway

Neurotrophin signaling pathway

Calcium signaling pathway

Jak-STAT signaling pathway

Insulin signaling pathway

Wnt signaling pathway

ErbB signaling pathway

Progesterone-mediated oocyte maturation

T cell receptor signaling pathway

Cell cycle

Endocytosis

Natural killer cell mediated cytotoxicity

Hematopoietic cell lineage

Toll-like receptor signaling pathway

Prostate cancer

Apoptosis

Colorectal cancer

GnRH signaling pathway

Axon guidance

Purine metabolism

Oocyte meiosis

Pancreatic cancer

Alzheimer's disease

Adherens junction

Tight junction

Melanogenesis

Ubiquitin mediated proteolysis

Leukocyte transendothelial migration

Chronic myeloid leukemia

Small cell lung cancer

Vascular smooth muscle contraction

Gap junction

Fc epsilon RI signaling pathway

Melanoma

Renal cell carcinoma

VEGF signaling pathway

Glioma

TGF-beta signaling pathway

Lysosome

Acute myeloid leukemia

B cell receptor signaling pathway

Huntington's disease

Cell adhesion molecules (CAMs)

Dilated cardiomyopathy

Non-small cell lung cancer

Adipocytokine signaling pathway

Endometrial cancer

Fc gamma R-mediated phagocytosis

Hypertrophic cardiomyopathy (HCM)

Long-term potentiation

Complement and coagulation cascades

p53 signaling pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Long-term depression

NOD-like receptor signaling pathway

Phosphatidylinositol signaling system

Olfactory transduction

ECM-receptor interaction

RIG-I-like receptor signaling pathway

Amyotrophic lateral sclerosis (ALS)

Epithelial cell signaling in Helicobacter pylori infection

Glycolysis / Gluconeogenesis

Bladder cancer

PPAR signaling pathway

Thyroid cancer

Pathogenic Escherichia coli infection

Type II diabetes mellitus

mTOR signaling pathway

Antigen processing and presentation

Inositol phosphate metabolism

Drug metabolism - cytochrome P450

Metabolism of xenobiotics by cytochrome P450

Basal cell carcinoma

Cardiac muscle contraction

Retinol metabolism

Valine

Glycerophospholipid metabolism

Cytosolic DNA-sensing pathway

Hedgehog signaling pathway

Viral myocarditis

Arginine and proline metabolism

Base excision repair

Glycerolipid metabolism

Pyrimidine metabolism

leucine and isoleucine degradation

Primary immunodeficiency

Arachidonic acid metabolism

Parkinson's disease

Fatty acid metabolism

Drug metabolism - other enzymes

Lysine degradation

Nucleotide excision repair

Vibrio cholerae infection

Tyrosine metabolism

Autoimmune thyroid disease

Glutathione metabolism

Prion diseases

Taste transduction

Fructose and mannose metabolism

Pyruvate metabolism

Sphingolipid metabolism

Tryptophan metabolism

SNARE interactions in vesicular transport

Butanoate metabolism

Notch signaling pathway

Systemic lupus erythematosus

Starch and sucrose metabolism

Amino sugar and nucleotide sugar metabolism

Nitrogen metabolism

Galactose metabolism

Histidine metabolism

Proteasome

Type I diabetes mellitus

Linoleic acid metabolism

Pentose phosphate pathway

Propanoate metabolism

Regulation of autophagy

Alanine

Cysteine and methionine metabolism

aspartate and glutamate metabolism

Dorso-ventral axis formation

Androgen and estrogen metabolism

Homologous recombination

Maturity onset diabetes of the young

Oxidative phosphorylation

Renin-angiotensin system

Ether lipid metabolism

Allograft rejection

Ribosome

beta-Alanine metabolism

Citrate cycle (TCA cycle)

Porphyrin and chlorophyll metabolism

Mismatch repair

Riboflavin metabolism

Aminoacyl-tRNA biosynthesis

DNA replication

Glycosaminoglycan degradation

Pantothenate and CoA biosynthesis

Phenylalanine metabolism

Spliceosome

Other glycan degradation

ABC transporters

Glycine

Selenoamino acid metabolism

serine and threonine metabolism

C21-Steroid hormone metabolism

Circadian rhythm - mammal

Graft-versus-host disease

leucine and isoleucine biosynthesis

N-Glycan biosynthesis

Primary bile acid biosynthesis

Asthma

Non-homologous end-joining

Folate biosynthesis

alpha-Linolenic acid metabolism

Ascorbate and aldarate metabolism

Basal transcription factors

Limonene and pinene degradation

Steroid biosynthesis

Terpenoid backbone biosynthesis

Pentose and glucuronate interconversions

Synthesis and degradation of ketone bodies

Glycosphingolipid biosynthesis - globo series

Glyoxylate and dicarboxylate metabolism

RNA degradation

Thiamine metabolism

Glycosphingolipid biosynthesis - lacto and neolacto series

Nicotinate and nicotinamide metabolism

One carbon pool by folate

Sulfur metabolism

Ubiquinone and other terpenoid-quinone biosynthesis

Biosynthesis of unsaturated fatty acids

Caffeine metabolism

Fatty acid elongation in mitochondria

Methane metabolism

RNA polymerase

Taurine and hypotaurine metabolism

Fatty acid biosynthesis

Glycosphingolipid biosynthesis - ganglio series

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Heparan sulfate biosynthesis

O-Glycan biosynthesis

Phenylalanine

Protein export

tyrosine and tryptophan biosynthesis

Vitamin B6 metabolism

Biotin metabolism

Chondroitin sulfate biosynthesis

D-Arginine and D-ornithine metabolism

D-Glutamine and D-glutamate metabolism

Keratan sulfate biosynthesis

1