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OriGene proteins in recent publications

Fully functional proteins purified from transient TrueORF cDNA clone transfections.  Researchers purified GEN1 protein using anti-FLAG M2 affinity column and determined it resolved Holliday junction X0 efficiently in vitro, thus confirming GEN1 is human Holliday junction resolvase.

Identification of Holliday junction resolvases from humans and yeast, Stephen C. Y. Ip, Ulrich Rass, Miguel G. Blanco, Helen R. Flynn, J. Mark Skehel, Stephen C. West, Nature 456, 357 - 361 (20 Nov 2008), doi: 10.1038/nature07470,


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TNFSF10 (NM_003810) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP750004-1000 Recombinant protein of human TRAIL (TNFSF10) produced in E. coli., 1 mg (Larger pack size?) ¥15000.00
¥3500.00
现货
TA50011-100 4C5, Anti-DDK monoclonal antibody (100 μL) ¥1000 现货
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Also for TNFSF10 (NM_003810)

OriGene Data
Species:Human Expression Host:E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC207596, encoding the region (Arg115-Gly281) of Trail
Tag:Tag-free Predicted MW:19.5 kDa
Purity:>95% as determined by SDS-PAGE and Coomassie blue staining
Concentration:Resuspend the protein to the desired concentration in proper buffer.
Buffer:Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.4. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Endotoxin: <0.1 EU per 1 ?g of the protein by the LAL
BioActivity: Measured?by?its ability to induce apoptotic cell death in TRAIL-sensetive RPMI-822polyhistidine effect is typically 6.9 - 10.3 ng/ml.
Protein Families: Transmembrane
Druggable Genome
Protein Pathways: Cytokine-cytokine receptor interaction
Apoptosis
Natural killer cell mediated cytotoxicity
Protein Data
  Protein Image
 

Reference Data
RefSeq: NP_003801 RefSeq Size: 1776 RefSeq ORF: 846
LocusID: 8743 Cytogenetic: 3q26.31  
Synonyms : Apo-2L; APO2L; CD253; TL2; TRAIL; TNLG6A
Summary: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProtKB/Swiss-Prot Function]
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag? is a registered trademark of Sigma-Aldrich

 

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