ATM Mouse Monoclonal Antibody [Clone ID: 3E8]

Specifications

Product Data
Clone Name	3E8
Applications	IHC, IP, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 5 µg/ml. Immunoprecipitation. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein expressed in E. coli corresponding to amino acids 980-1512
Specificity	This antibbody detects Ataxia Telangiectasia Mutated (ATM).
Formulation	Phosphate buffered saline, pH 7.4 State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2-8 °C for on month or (in aliquots) at -20 °C for long term. Avoid repeated freezing and thawing.
Gene Name	ATM serine/threonine kinase
Database Link	Entrez Gene 472 Human UniProt ID Q13315
Background	ATM-3E8 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.
Synonyms	Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ATDC, TEL1, TELO1
Reference Data

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