gamma Catenin (JUP) Mouse Monoclonal Antibody [Clone ID: 15F11]

Specifications

Product Data
Clone Name	15F11
Applications	IF, IP, WB
Recommend Dilution	Immunoflourescence with cells fixed in paraformaldehyde: The typical starting working dilution is 1/10. Immunoprecipitation. Western blot: The typical starting working dilution is 1/10.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody detects Plakoglobin.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted  at 2-8°C.
Gene Name	junction plakoglobin
Database Link	Entrez Gene 3728 Human UniProt ID P14923
Background	Plakoglobin, also known as gamma-catenin belongs together with alpha- and beta catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoglobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas.
Synonyms	Desmoplakin-3, Desmoplakin III, Catenin gamma, JUP, CTNNG, DP3
Reference Data

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