PROCR Rat Monoclonal Antibody [Clone ID: LMR-42]

Specifications

Product Data
Clone Name	LMR-42
Applications	IHC
Recommend Dilution	Flow Cytometry: No cell permeabilization required. Immunohistochemistry on Frozen Sections: 1/20 (air-dried or acetone fixed cells).
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Specificity	This Rat Monoclonal antibody clone LMR-42 detects an outer-surface epitope of a 55 kDa plasma membrane protein overexpressed in several Human non-Pgpmultidrug-resistant (MDR) tumor cell lines. Expression cloning revealed that the LMR-42 antigen is identical to the Human Endothelial Cell Protein Receptor (EPCR). Protein C is the zymogen of the key anticoagulant enzyme, activated protein C (APC). LMR-42 has potential value for the detection of EPCR, which may mediate anti-coagulant and anti-inflammatory functions along vascular endothelia. Whether and how anti-coagulant and anti-inflammatory functions of EPCR facilitate oncogenesis and/or drug-resistance is unclear.
Formulation	State: Supernatant State: Serum Free Culture Supernatant Stabilizer: 0.7% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein C receptor
Database Link	Entrez Gene 10544 Human UniProt ID Q9UNN8
Background	PROCR (CD201) is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in its gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
Synonyms	PROCR, Endothelial protein C receptor, APC receptor
Reference Data

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