ASF1B Mouse Monoclonal Antibody [Clone ID: AT1D4]
CAT#: AM50339PU-S
ASF1B mouse monoclonal antibody, clone AT1D4, Purified
Size: 100 ul
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CNY 5,630.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | AT1D4 |
Applications | ELISA, WB |
Recommend Dilution | The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant human ASF1B (1-202aa) purified from E. coli. |
Specificity | Recognizes Human ASF1B. Other species not tested. |
Formulation | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | anti-silencing function 1B histone chaperone |
Database Link | |
Background | ASF1B is a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. Delivering histone H3/H4 dimers to CAF-1 or HIRA histone deposition complexes to facilitate replication-coupled and replication-independent nucleosome assembly on DNA. Both ASF1A and ASF1B are phosphorylated in S phase by the Tousled-like kinases TLK1 and TLK2, and are dephosphorylated when TLK1 and TLK2 are inactivated by Chk1 kinase in response to replicative stress. |
Synonyms | CCG1-interacting factor A-II, CIA-II |
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