beta Catenin (CTNNB1) pThr41/pSer45 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1/500-1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	p-Catenin-β (pThr41+S45) antibody detects endogenous levels of p-Catenin-β protein.
Formulation	Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	1.0 mg/ml
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 85 kDa
Gene Name	catenin beta 1
Database Link	Entrez Gene 1499 Human UniProt ID P35222
Background	The catenins, α, β and γ, are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play critical roles in mediating cellular adhesion. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin also forms complexes with the tumor suppressor protein APC. Amino acid alterations at residues around Ser 33, one of the targets for phosphorylation of glycogen synthase kinase-3β, results in accumulation of the β-catenin protein in the cytoplasm and nucleus. Pin1 is a novel regulator of β-catenin signaling that directly binds a phosphorylated Ser-Pro motif next to the APC-binding site in β-catenin, inhibiting the interaction with APC, and increasing β-catenin translocation into the nucleus. Thus, Pin1 overexpression may contribute to the upregulation of β-catenin in tumors such as breast cancer.
Synonyms	CTNNB1, CTNNB, Beta-catenin
Reference Data

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