MAGI3 (PDZ 4-5) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1 - 10 µg/ml. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Recombinant protein corresponding to PDZ domain 4-5 of MAGI-3.
Specificity	This antibody reacts to M A G I - 3 , P D Z 4 - 5 .
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig (0.2 µm sterile filtered)
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	membrane associated guanylate kinase, WW and PDZ domain containing 3
Database Link	Entrez Gene 260425 Human UniProt ID Q5TCQ9
Background	Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is then followed by 6 PDZ domains.
Synonyms	MAGI-3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Tight junction

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