TRPM8 Rabbit Polyclonal Antibody

CAT#: AP10556SU-N

TRPM8 rabbit polyclonal antibody, Serum



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CNY 6,600.00


货期*
8周

规格
    • 200 ul

Product images

Specifications

Product Data
Applications ELISA, IHC, WB
Recommend Dilution

ELISA.
Western Blot: 1/200-1/2000.
Immunohistochemistry: 1/50-1/500.

Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from an internal domain of the Human TRPM8 protein.
Specificity This antibody reacts with 127 kDa protein.
Formulation State: Serum
State: Lyophilized serum
Preservative: None
Reconstitution Method Restore in distilled water.
Conjugation Unconjugated
Storage Condition

Prior to reconstitution store the antibody at -20°C.
Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name transient receptor potential cation channel subfamily M member 8
Background TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Synonyms TRPP8, Trp-p8, LTRPC6
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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