SC35 (SRSF2) (Center) Rabbit Polyclonal Antibody
CAT#: AP18194PU-N
SC35 (SRSF2) (Center) rabbit polyclonal antibody
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CNY 6,160.00
货期*
5周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | ELISA: 1/1,000. Western blotting: 1/50 - 1/100. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide selected from aa 83-113 from the Center region of human SFRS2 |
Specificity | This antibody reacts to SFRS2. |
Formulation | PBS with 0.09% (W/V) sodium azide State: Liquid purified Ig |
Concentration | lot specific |
Purification | Saturated Ammonium Sulfate (SAS) precipitation |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | serine/arginine-rich splicing factor 2 |
Database Link | |
Background | SFRS2 is necessary for the splicing of pre-mRNA. The protein is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. And it interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. It binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3' and can bind to beta-globin mRNA and commit it to the splicing pathway. |
Synonyms | Splicing factor SC35, Splicing component 35 kDa, PR264, Nuclear Speckle Marker |
Reference Data | |
Protein Families | Stem cell - Pluripotency, Transcription Factors |
Protein Pathways | Spliceosome |
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