Caspase-7 (CASP7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL, ICC: 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Caspase-7 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human Caspase-7.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 7
Database Link	NP_001218 Entrez Gene 12369 MouseEntrez Gene 64026 RatEntrez Gene 840 Human UniProt ID P55210
Background	Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3 (4). Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms (4). Caspase-7 activity can be directly inhibited by XIAP expression (5).
Synonyms	CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Alzheimer's disease, Apoptosis

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