IL31 Rabbit Polyclonal Antibody

CAT#: TA306295

Rabbit Polyclonal IL-31 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Transient overexpression lysate of interleukin 31 (IL31)
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 2.5 - 10 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen IL-31 antibody was raised against a 18 amino acid peptide from near the center of human IL-31.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name interleukin 31
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).
Synonyms IL-31
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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