CDC42 binding protein kinase alpha (CDC42BPA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment contain a sequence corresponding to a region within amino acids 373 and 564 of MRCK alpha
Formulation	1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Affinity purified by Protein A.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	186 kDa
Gene Name	CDC42 binding protein kinase alpha
Database Link	NP_003598 Entrez Gene 8476 Human UniProt ID Q5VT25
Background	The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq]
Synonyms	MRCK; MRCKA; PK428
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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