Gabbr1 Mouse Monoclonal Antibody [Clone ID: S93A-49]

Specifications

Product Data
Clone Name	S93A-49
Applications	WB
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABA(B)R1
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	gamma-aminobutyric acid type B receptor subunit 1
Database Link	NP_112290 Entrez Gene 2550 HumanEntrez Gene 54393 MouseEntrez Gene 81657 Rat UniProt ID Q9Z0U4
Background	GABA (-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system andinteracts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission . Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site . Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein . G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibitthrough coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation .
Synonyms	dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA-B-R1; GABABR1; GABBR1-3; GB1; GPRC3A; hGB1a; OTTHUMP00000109099
Note	Detects ~115kDa. No cross-reactivity against GABA(B)R2
Reference Data

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