alpha 1 Fetoprotein (AFP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Mouse, Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	C term -peptide of human AFP
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	65 kDa
Gene Name	alpha fetoprotein
Database Link	NP_001125 Entrez Gene 11576 MouseEntrez Gene 24177 RatEntrez Gene 174 Human UniProt ID P02771
Background	Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the serum of the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells. The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Elevated serum levels are predictive of hepatocellular carcinoma.
Synonyms	AFPD; FETA; HPAFP
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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