Annexin V (ANXA5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human ANXA5
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	annexin A5
Database Link	NP_001145 Entrez Gene 11747 MouseEntrez Gene 308 Human UniProt ID P08758
Background	Annexin V, also known as PAP-1 or Lipocortin V, is a ~30 kDa protein that binds to phospholipids in a calcium-dependent manner. All annexins contain a putative PKC binding site, but only annexin V has been identified as an inhibitor of this pathway. It may also signal, by direct interaction with VEGFR2 receptor, in the regulation of vascular endothelial cell proliferation. Annexin V preferentially binds phosphatidylserine, in competition with prothrombin, leading to inhibition of blood coagulation at sites of injury preceding contact between lipid components and coagulation factors that initiate thrombosis . The ability of Annexin V to bind specifically and robustly to phosphatidylserine makes it an attractive reagent in detecting apoptotic cells. Annexin V is inducible by glucocorticoids and can be phosphorylated by tyrosine and serine/threonine kinases. It is thought to block production of mediators of inflammation, such as prostaglandins and leukotrienes by inhibiting the release of arachidonic acid from membranes by phospholipase A2.
Synonyms	ANX5; ENX2; HEL-S-7; PP4; RPRGL3
Reference Data

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