Kcng1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)RRKPSTGNSYLDK, corresponding to amino acid residues 325- 337 of mouse Kv6.1 . 2nd extracellular loop.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel, subfamily G, member 1
Database Link	NP_001074603 Entrez Gene 296395 RatEntrez Gene 241794 Mouse UniProt ID A2BDX4
Background	Voltage-gated K+ channels are transmembrane proteins consisting of four a-subunits arranged in a radially symmetric fashion around a central aqueous pore. Each a-subunit consists of six transmembrane segments (S1-S6) with cytoplasmic NH2- and COOH-termini.In mammals, a large family of genes encodes a-subunits: KV1 (homologous to Drosophila Shaker), KV2 (Shab), KV3 (Shaw), KV4 (Shal), KV5, KV6, and KV91. The sparsely populated KV channel subfamilies KV5 and KV6 each contain one member, KV5.1 and KV6.12. KV6 channels are electrically silent and no functional role has been suggested for these channels3. A recent study found that KV6.1 forms functional channels specifically with KV2.13. It was also found that KV2.1 and KV6.1 mRNAs colocalize to the piriform cortex, hippocampus, dendate gyrus and olfactory tubercle in the brain4 and to SA node, atria and ventricle in the heart5. This suggests that KV6.1 may be physiologically important in generating an increased number of KV channel phenotypes even though it does not itself form functional homomultimeric channels. Another study found that KV6.1 regulates the kinetics of KV2.2 channels. KV2.1/6.1 coexpression results in channels with markedly slower inactivation during strong depolarization but faster inactivation at intermediate potentials.
Synonyms	K13; KCNG; kH2; KV6.1; MGC12878
Reference Data

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