DBF4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the N-terminus of DBF4 protein. This sequence is identical to human, rat and mouse.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~77 kDa
Gene Name	DBF4 zinc finger
Database Link	NP_006707 Entrez Gene 27214 MouseEntrez Gene 312046 RatEntrez Gene 10926 Human UniProt ID Q9UBU7
Background	The human DBF4/ASK protein contains a putative site for phosphorylation by CDK, PEST protease cleavage sites, nuclear localization signals and a short-looped zinc finger-like domain. DBF4 interacts physically with CDC7 and MCM2 as a cyclin-like regulatory subunit of mammalian CDC7, thus it plays a key role in the regulation of DNA replication during the cell cycle in all eukaryotes. The DBF4/ASK is also identified as a novel determinant for melanoma development. The up-regulation of ASK/DBF4 is a novel molecular determinant with prognostic relevance that confers a proliferative advantage in melanoma.
Synonyms	ASK; CHIF; DBF4A; ZDBF1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle

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