KRR1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-300 Positive control: Human thyroid cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human KRR1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Gene Name	KRR1, small subunit processome component homolog
Database Link	Entrez Gene 11103 Human UniProt ID Q13601
Background	The SSU is a large ribonucleoprotein consisting of at least 40 proteins and the U3 small nucleolar RNA. It is involved in pre-rRNA processing and ribosome assembly. The SSU is necessary for the biogenesis of the 18S rRNA. Cells that are depleted of SSU proteins will arrest in the G1 phase of the cell cycle. KRR1, also known as HRB2 (HIV-1 Rev binding protein 2) or RIP-1 (Rev interacting protein 1), is a nonribosomal component of the small subunit processome (SSU). KRR1 is 381 amino acids in length and is evolutionarily conserved among human, yeast, fly, nematode and rice. KRR1 localizes to the nucleolus and is highly expressed in dividing cells. It contains one conserved KH domain (RNA-binding motif) and is a crucial component of the SSU, required for both rRNA maturation and ribosome biogenesis.
Synonyms	HRB2; RIP-1
Reference Data

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