IFI35 Rabbit Polyclonal Antibody
CAT#: TA368533
IFI35 rabbit polyclonal antibody
Size: 25 ul
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CNY 1,999.00
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Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 30-150 Positive control: Human breast cancer Predicted cell location: Nucleus |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human IFI35 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C. |
Gene Name | interferon induced protein 35 |
Database Link | |
Background | The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-α, IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN-α signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-α. Two isoforms of IFI-35 exist due to alternative splicing events. |
Synonyms | FLJ21753; IFP35 |
Reference Data |
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