TIRAP Rabbit Polyclonal Antibody
CAT#: TA382551
TIRAP Rabbit polyclonal Antibody
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货期*
2周
规格
经常一起买 (1)
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Specifications
Product Data | |
Applications | ICC/IF, WB |
Recommend Dilution | WB,1:500 - 1:2000 IF,1:50 - 1:200 |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP (NP_001034750.1). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 23kDa/25kDa/27kDa |
Gene Name | toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
Database Link | |
Background | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
Synonyms | FLJ42305; Mal; OTTHUMP00000179130; wyatt |
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