VCIP 135 (VCPIP1) Rabbit Polyclonal Antibody
CAT#: TA383208
VCPIP1 Rabbit polyclonal Antibody
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货期*
2周
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB,1:500 - 1:2000 |
Reactivity | Human, Mouse |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 923-1222 of human VCPIP1 (NP_079330.2). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 134kDa |
Gene Name | valosin containing protein interacting protein 1 |
Database Link | |
Background | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER (By similarity. Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. |
Synonyms | DKFZp686G038; DUBA3; FLJ23132; FLJ60694; KIAA1850; VCIP135 |
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