CDK5RAP3 Rabbit Monoclonal Antibody [Clone ID: R07-1A1]
CAT#: TA383970S
CDK5RAP3 Rabbit monoclonal Antibody
Size: 100 ul
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Specifications
Product Data | |
Clone Name | R07-1A1 |
Applications | IHC, IP, WB |
Recommend Dilution | WB: 1/1000 IHC: 1/20 IP: 1/20 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human CDK5RAP3 |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Predicted Protein Size | Calculated MW: 57 kDa; Observed MW: 70 kDa |
Gene Name | CDK5 regulatory subunit associated protein 3 |
Database Link | |
Background | Swiss-Prot Acc.Q96JB5.Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). |
Synonyms | C53; FLJ13660; HSF-27; IC53; LZAP; MST016; OK/SW-cl.114 |
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