GCNF (NR6A1) Rabbit Polyclonal Antibody
CAT#: TA392528S
NR6A1 polyclonal antibody
Size: 100 ul
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:2000~1:5000 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to Human NR6A1. |
Specificity | NR6A1 polyclonal antibody detects endogenous levels of NR6A1 protein. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 50 kDa |
Gene Name | nuclear receptor subfamily 6 group A member 1 |
Database Link | |
Background | GCNF (Germ Cell Nuclear Factor), also known as NR6A1 (Nuclear Receptor Subfamily 6 Group A member), is an orphan member of the nuclear receptor gene superfamily. It has been shown to be expressed in the nervous system during development and during specific stages in maturing germ cells of the ovary and testis in the adult, and has probable roles in gametogenesis, neurogenesis, and normal embryonic development during gastrulation. Inactivation of GCNF in mouse results in abnormal posterior development, impaired midbrain development, insufficient closure of the neural tube, and eventual embryonic death. GCNF has been shown to be a repressor of OCT-4 and of the protamine genes and plays a critical role in the control of gene expression during embryogenesis and spermatogenesis. |
Synonyms | GCNF; Germ cell nuclear factor; hGCNF; hRTR; NR6A1; Nuclear receptor subfamily 6 group A member 1; Retinoid receptor-related testis-specific receptor; RTR |
Note | For research use only, not for use in diagnostic procedure. |
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