H3C14 Rabbit Polyclonal Antibody
CAT#: TA397542
Histone H3 K9-Ac/phospho S10 (RABBIT) Antibody
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CNY 8,363.00
货期*
4周
规格
经常一起买 (2)
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Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 1.0 µg/mL IF: 1:10 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Anti-Histone H3 [ac Lys9/phospho Ser10] affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide with a acetylation surrounding Lysine 9 and a phosphorylation surrounding serine 10 of human Histone H3. |
Specificity | Anti-Histone H3 K9Ac/pS10 was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human Histone H3. Cross-reactivity with other sources has not been determined. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
Concentration | 0.25 mg/mL - lot specific |
Conjugation | Unconjugated |
Storage Condition | Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. |
Gene Name | histone cluster 2, H3c |
Database Link | |
Background | Histones of the nucleosome build chromatin and undergo various post-translational modifications proven to regulate chromatin condensation and DNA accessibility. Phosphorylations on Serine 10 has been shown to facilitate chromatin condensation by its interaction with Aurora-B kinase during mitosis and is alternatively active in cell division. Serine modification is associated with IKK-alpha and Snf1 enzymes in transcriptional activation, and is modified by MSK1 and 2 which are enzymes that react to growth factors and cellular stress in immediate-early gene activation. Lysine 9 acetylations are connected with histone deposition and transcriptional activation. Anti-Histone H3 [ac Lys9/phospho Ser10] antibody is ideal for researchers interested in Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, and Epigenetics research. |
Synonyms | rabbit anti-Histone H3 Ac Lys9 pS10 antibody, Histone H3 antibodies, H3K9ac/pS10 |
Note | Anti-Histone H3 K9-Ac/pS10 antibody is tested for Western Blot, Dot Blot, and Immunocytochemistry/Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~15 kDa corresponding to Histone H3 protein by Western Blotting in NIH-3T3 histone prep lysate or the appropriate cell lysate or extract. Epi-Plus™ antibody production in collaboration with Novus Biologicals. |
Reference Data | |
Protein Pathways | Systemic lupus erythematosus |
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