USP5 Mouse Monoclonal Antibody [Clone ID: OTI1F8]

Specifications

Product Data
Clone Name	OTI1F8
Applications	IHC, WB
Recommend Dilution	WB 1:1000~2000, IHC 1:50
Reactivity	Human, Dog, Rat, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human USP5 (NP_003472) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.7 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	93.1 kDa
Gene Name	ubiquitin specific peptidase 5
Database Link	NP_003472 Entrez Gene 297593 RatEntrez Gene 486718 DogEntrez Gene 714032 MonkeyEntrez Gene 8078 Human UniProt ID P45974
Background	Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]). [supplied by OMIM]
Synonyms	ISOT
Reference Data
Protein Families	Druggable Genome, Protease

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