ALK (CD246) mouse monoclonal antibody, clone OTI1A4
CAT#: UM800118
ALK (CD246)mouse monoclonal antibody, clone OTI1A4
View other "OTI1A4" antibodies (7)
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CNY 2,999.00
Cited in 22 publications. |
CNY 4,840.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 9,998.00
Specifications
Product Data | |
Clone Name | OTI1A4 |
Applications | IHC, LMNX, WB |
Recommend Dilution | WB 1:2000, IHC: 1:100 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 1300-1620 of human ALK (NP_004295) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 176.3 kDa |
Gene Name | ALK receptor tyrosine kinase |
Database Link | |
Background | This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). [provided by RefSeq, Jan 2011] |
Synonyms | CD246; NBLST3 |
Note | The clone was previously sold as TA801287 before being upgraded to UltraMAB. |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Citations (22)
The use of this Antibodies has been cited in the following citations: |
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Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing
,Conde, E;Rojo, F;G?mez, J;Enguita, AB;Abdulkader, I;Gonz?lez, A;Lozano, D;Manche?o, N;Salas, C;Salido, M;Salido-Ruiz, E;de ?lava, E;,
Journal of clinical pathology
,PubMed ID 33875457
[ALK]
|
Effect of hnRNPA2/B1 on the proliferation and apoptosis of glioma U251 cells via the regulation of AKT and STAT3 pathways
,Yin, D;Kong, C;Chen, M;,
Biosci. Rep.
,PubMed ID 32463472
[ALK]
|
Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma
,Murali, P;Johnson, BP;Lu, Z;Climer, L;Scott, DA;Foulquier, F;Oprea-Ilies, G;Lupashin, V;Drake, RR;Abbott, KL;,
Oncotarget
,PubMed ID 32733646
[ALK]
|
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
,Hosur, V;Low, BE;Li, D;Stafford, GA;Kohar, V;Shultz, LD;Wiles, MV;,
Genome Biol.
,PubMed ID 32646486
[ALK]
|
Gene rearrangements in consecutive series of pediatric inflammatory myofibroblastic tumors
,Preobrazhenskaya, EV;Iyevleva, AG;Suleymanova, AM;Tiurin, VI;Mitiushkina, NV;Bizin, IV;Ivanstov, AO;Gorustovich, OA;Shelekhova, KV;Kachanov, DY;Varfolomeeva, SR;Roschin, VY;Kazakova, AN;Litvinov, DV;Shamanskaya, TV;Savelov, NA;Suspitsin, EN;Imyanitov, EN;,
Pediatr Blood Cancer
,PubMed ID 32064735
[ALK]
|
ALK testing methods: Is there a winner or loser?
,Kozuma, Y;Toyokawa, G;Seto, T;,
Expert Rev Anticancer Ther
,PubMed ID 30576255
[ALK]
|
A Novel EML6-ALK FBXO11-ALK Double Fusion Variant in Lung Adenocarcinoma and Response to Crizotinib
,Lin, H;Ren, G;Liang, X;,
J Thorac Oncol
,PubMed ID 30368418
[ALK]
|
ALK (D5F3) CDx: an immunohistochemistry assay to identify ALK-positive NSCLC patients
,Uruga, H;Mino-Kenudson, M;,
PGPM
,PubMed ID 30271189
[ALK]
|
A subgroup of pleural mesothelioma expresses ALK protein and may be targetable by combined rapamycin and crizotinib therapy
,Mönch, D;Bode-Erdmann, S;Kalla, J;Sträter, J;Schwänen, C;Falkenstern-Ge, R;Klumpp, S;Friedel, G;Ott, G;Kalla, C;,
Oncotarget
,PubMed ID 29755689
[ALK]
|
Worse disease-free, tumor-specific, and overall survival in surgically-resected lung adenocarcinoma patients with ALK rearrangement
,Gao, Q;Li, P;Jiang, X;Zhan, Z;Yan, Q;Zhang, B;Huang, C;,
Oncotarget
,PubMed ID 29156778
[ALK]
|
ALK in Non-Small Cell Lung Cancer (NSCLC) Pathobiology, Epidemiology, Detection from Tumor Tissue and Algorithm Diagnosis in a Daily Practice
,Hofman, P;,
Cancers (Basel) 2017
,PubMed ID 28805682
[ALK]
|
Immunohistochemistry of Pulmonary Biomarkers: A Perspective From Members of the Pulmonary Pathology Society
,Thunnissen, E;Allen, TC;Adam, J;Aisner, DL;Beasley, MB;Borczuk, AC;Cagle, PT;Capelozzi, VL;Cooper, W;Hariri, LP;Kern, I;Lantuejoul, S;Miller, R;Mino-Kenudson, M;Radonic, T;Raparia, K;Rekhtman, N;Roy-Chowdhuri, S;Russell, P;Schneider, F;Sholl, LM;Tsao, MS;Vivero, M;Yatabe, Y;,
Arch. Pathol. Lab. Med.
,PubMed ID 28686497
[ALK]
|
ALK evaluation in the world of multiplex testing: Network Genomic Medicine (NGM): the Cologne model for implementing personalised oncology
,Heydt, C;Kostenko, A;Merkelbach-Bruse, S;Wolf, J;Büttner, R;,
Ann. Oncol.
,PubMed ID 27573753
[ALK]
|
Antibody 1A4 with routine immunohistochemistry demonstrates high sensitivity for ALK rearrangement screening of Chinese lung adenocarcinoma patients: A single-center large-scale study
,Wang, Q;Zhao, L;Yang, X;Wei, S;Zeng, Y;Mao, C;Lin, L;Fu, P;Lyu, L;Li, Z;Xiao, H;,
Lung Cancer
,PubMed ID 27040850
[ALK]
|
ALK-Testung beim nicht-kleinzelligen Lungenkarzinom (NSCLC): Immunhistochemie (IHC) und/oder Fluoreszenz-in-situ-Hybridisierung (FISH)?
,von Laffert, M;Schirmacher, P;Warth, A;,
Pneumologie
,PubMed ID 26984109
[ALK]
|
Stellungnahme der DGP und der AG Thorakale Onkologie der AG Onkologie/Deutsche Krebsgesellschaft e. V. zur ALK-Testung beim NSCLC
,von Laffert, M;Schirmacher, P;Warth, A;Weichert, W;,
Der Pathologe
,PubMed ID 26984297
[ALK]
|
Brief Report: Reliability assurance of EML4-ALK rearrangement detection in non-small cell lung cancer: the results of a proficiency testing in China
,Li, Y;Zhang, R;Peng, R;Ding, J;Han, Y;Wang, G;Zhang, K;Lin, G;Li, J;,
J Thorac Oncol
,PubMed ID 26988569
[ALK]
|
A new, highly sensitive ALK antibody improves the screening of rearranged-ALK by IHC
,Hsiangmin Lu, Rachel Gonzalez, Yi Shen, Mu-lan Jin, Yipan Wu, Yungang Zhang, Kehu Yuan, Boyang Chu, Lili Qi, Huibo Liu, Chenlin Wang, Guangli Wang, Youmin Shu, Julie McDowell, Donghui Ma, Wei-wu He, Jian Chen, Ray Lin,
AACR 2016 Abstract
[ALK]
|
NordiQC Immunohistochemistry Quality Control Run 45 2015 on Lung Anaplastic Lymphoma Kinase (Lu-ALK)
,Nordi QC Team,
NordiQC assessment Run 45 on ALK
[ALK]
|
Inflammatory myofibroblastic tumour of the bladder in children: A review
,Collin, M;Charles, A;Barker, A;Khosa, J;Samnakay, N;,
J Pediatr Urol
,PubMed ID 25982020
[ALK]
|
A Novel, Highly Sensitive ALK Antibody 1A4 Facilitates Effective Screening for ALK Rearrangements in Lung Adenocarcinomas by Standard Immunohistochemistry
,Gruber K, Kohlhäufl M, Friedel G, Ott G, Kalla C.,
J Thorac Oncol. 2015 Apr;10(4):713-6
,PubMed ID 25789835
[ALK]
|
Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy
,Wang, Q;He, Y;Yang, X;Wang, Y;Xiao, H;,
BMC Pulm Med
,PubMed ID 24885608
[ALK]
|
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抗体相关资料 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF801287 | Carrier-free (BSA/glycerol-free) ALK mouse monoclonal antibody, clone OTI1A4 (formerly 1A4) |
CNY 3,999.00 |
|
TA801287 | ALK mouse monoclonal antibody, clone OTI1A4 (discontinued and upgraded to UltraMAB UM800118) |
CNY 1,999.00 |
|
TA801287AM | ALK mouse monoclonal antibody,clone 1A4, Biotinylated |
CNY 3,990.00 |
|
TA801287BM | ALK mouse monoclonal antibody,clone 1A4, HRP conjugated |
CNY 3,990.00 |
|
TA801287S | ALK mouse monoclonal antibody, clone OTI1A4 (discontinued and upgraded to UltraMAB UM800118) |
CNY 800.00 |
|
UM800118CF | Carrier-free (BSA/glycerol-free) ALK mouse monoclonal antibody, clone OTI1A4 |
CNY 4,999.00 |
|
UM870118 | ALK mouse monoclonal antibody, clone OTI1A4 |
CNY 1,150.00 |