MED12 (NM_005120) Human 3' UTR Clone
CAT#: SC203118
3' UTR clone of mediator complex subunit 12 (MED12) for miRNA target validation
Need custom modification / cloning service?
Get a free quote
CNY 4,845.00
货期*
3周
规格
Product images
经常一起买 (2)
Specifications
Product Data | |
Product Name | MED12 (NM_005120) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | ARC240; CAGH45; FGS1; HOPA; Kto; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230 |
ACCN | NM_005120 |
Insert Size | 262 bp |
Sequence Data |
>SC203118 3’UTR clone of NM_005120
The sequence shown below is from the reference sequence of NM_005120. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCAGTACCAACATATTTGGACGCTACTGAGCCACCTGGAGGAACTGCTTGTGCACTGGATGTGGCCCC ACCCTTTCCTCTTAATTCCCAATCCCATTCCTGGGCTAGCACCAGTAGTGGTTGGGGCCCTCCCCTCAG GCTCCATTTTTAATAAGTTTTTAGTATTTTTGTTAATGTGAGGCATTGAGCTGTTGGGTTTTGTATATT ATTTATATAGAGACCCCAGAGCTGTTGCACCCAATACACAGAGCTTCTTTGCAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_005120.3 |
Synonyms | ARC240; CAGH45; FGS1; HOPA; Kto; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230 |
Summary | The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009] |
Locus ID | 9968 |
MW | 9.9 |
Documents
Product Manuals |
FAQs |
Resources
Customer
Reviews
Loading...