Repulsive Guidance Molecule C (HFE2) (NM_145277) Human 3' UTR Clone

Specifications

Product Data
Product Name	Repulsive Guidance Molecule C (HFE2) (NM_145277) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HFE2; HFE2A; JH; RGMC
ACCN	NM_145277
Insert Size	637 bp
Sequence Data	Insert Sequence (showhide) >SC208272 3’UTR clone of NM_145277 The sequence shown below is from the reference sequence of NM_145277. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTCTTTGTTCTGTGGCTTTGCATTCAGTAAGGGGACCATCAGTCCCATTACTAGTTTGGAAATGATTTG GAGATACAGATTGGCATAGAAGAATGTAAAGAATCATTAAAGGAAGCAGGGCCTAGGAGACACGTGAAA CAATGACATTATCCAGAGTCAGATGAGGCTGCAGTCCAGGGTTGAAATTATCACAGAATAAGGATTCTG GGCAAGGTTACTGCATTCCGGATCTCTGTGGGGCTCTTCACCAATTTTTCCAGCCTCATTTATAGTAAA CAAATTGTTCTAATCCATTTACTGCAGATTTCACCCTTATAAGTTTAGAGGTCATGAAGGTTTTAATGA TCAGTAAAGATTTAAGGGTTGAGATTTTTAAGAGGCAAGAGCTGAAAGCAGAAGACATGATCATTAGCC ATAAGAAACTCAAAGGAGGAAGACATAATTAGGGAAAGAAGTCTATTTGATGAATATGTGTGTGTAAGG TATGTTCTGCTTTCTTGATTCAAAAATGAAGCAGGCATTGTCTAGCTCTTAGGTGAAGGGAGTCTCTGC TTTTGAAGAATGGCACAGGTAGGACAGAAGTATCATCCCTACCCCCTAACTAATCTGTTATTAAAGCTA CAAATTCTTCACACCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_145277.5
Synonyms	HFE2; HFE2A; JH; RGMC
Summary	The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
Locus ID	148738
MW	24.5

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