DDB1 (NM_001923) Human 3' UTR Clone

Specifications

Product Data
Product Name	DDB1 (NM_001923) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
ACCN	NM_001923
Insert Size	715 bp
Sequence Data	Insert Sequence (showhide) >SC209130 3’UTR clone of NM_001923 The sequence shown below is from the reference sequence of NM_001923. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTTGTGGAGGAGCTAACTCGGATCCATTAGCCAAGGGCAGGGGGCCCCTTTGCTGACCCTCCCCAAAGG CTTTGCCCTGCTGCCCTCCCCCTCCTCTCCACCATCGTCTTCTTGGCCATGGGAGGCCTTTCCCTAAGC CAGCTGCCCCCAGAGCCACAGTTCCCCTATGTGGAAGTGGGGCGGGCTTCATAGAGACTTGGGAATGAG CTGAAGGTGAAACATTTTCTCCCTGGATTTTTACCAGTCTCACATGATTCCAGCCATCACCTTAGACCA CCAAGCCTTGATTGGTGTTGCCAGTTGTCCTCCTTCCGGGGAAGGATTTTGCAGTTCTTTGGCTGAAAG GAAGCTGTGCGTGTGTGTGTGTGTATGTGTGTGTGTGTATGTGTATCTCACACTCATGCATTGTCCTCT TTTTATTTAGATTGGCAGTGTAGGGAGTTGTGGGTAGTGGGGAAGAGGGTTAGGAGGGTTTCATTGTCT GTGAAGTGAGACCTTCCTTTTACTTTTCTTCTATTGCCTCTGAGAGCATCAGGCCTAGAGGCCTGACTG CCAAGCCATGGGTAGCCTGGGTGTAAAACCTGGAGATGGTGGATGATCCCCACGCCACAGCCCTTTTGT CTCTGCAAACTGCCTTCTTCGGAAAGAAGAAGGTGGGAGGATGTGAATTGTTAGTTTCTGAGTTTTACC AAATAAAGTAGAATATAAGAAGAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001923.5
Synonyms	DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
Summary	The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
Locus ID	1642
MW	27.1

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