NUMBL (NM_004756) Human 3' UTR Clone

Specifications

Product Data
Product Name	NUMBL (NM_004756) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23
ACCN	NM_004756
Insert Size	1593 bp
Sequence Data	Insert Sequence (showhide) >SC215309 3’UTR clone of NM_004756 The sequence shown below is from the reference sequence of NM_004756. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTGCAAAAGACATTCGAGATTGAACTGTAGCCCGAGCCGCCCCACCCACTCCATCATCTCCAGGTGCCC CACGCCTGGGGGTGGAGGCACAACCTCTCCCCTAACCCTGCTCCCTGGGGCTGCGCCCCTCAACACCCT CTCAACACCCCCCTCCCTCAACCACCCCGACAACCACTACAGAACCAACATTGTGACGCCCAGGTTGCA ACAGGATGGAATTCAGGGACGGACCCAGCCTGGCTAAGGGAACCATTTCACTGCCGGACTTAGGCTGGC AATGCCCCCTTCCCCAACCCCAGACACAGGGGTTGGCCACAATCCCACTGAATGCCCTTGGTTCACACT CCATTTCCCAGTTTCTGTTGACCCCCACCTTCCAGTGTTGGACAGGATGGAGGGGGGACACTTGCTTAG GGGCTCTCCTGGGCCCCACACCAGTGCCCACCCCAAATCTGGTCGTCTCCTCCCCCCATGCACAGCACA AGCTAAGGGCTGCCCTCTGCCCACACGCTGCGTTCACTGCCAATGCTGTACTCACCTCCATCACCCTCC AACTTTGGGGCCCATGTCTTCCTTGGGCCAAGGTCTCATGGGGGCTAGGGCCAAGTTGGGGGCCCAGGA GGCGGGGAGGGAGGAGGAGGAGAAGATGCGCAGTTACCTCATGTCGGTGCCCGCTGGGGAGGGGTCCGG GAAGAAGGGGAAGGGGTGCCTGGCGGGTACTTTTCTATCTTTTATTTCCAGATTTTTTTTGTATCTAAA CTTGAAGATTTGTATTATACAAGGACAGCCAATAAAGGAAGAATATAATGGTGCCCCTCGGGAAACGAG GGTGTGTGTAGGGCGCTGGTGAGGCCCTAGAACCTTTCCTCCTGAGTCATGGACTGAAACAGAGTCAGA AGGATGTCCCTGAGTGATAACCTCTGAGTCATAGCGTGGTAACAGGTACCACTGACTCAGCACCTGCCA GGCGGGTATTAAAGGAGCCAAAATTAATCACCCCATTTCTATTCCTTACAGAGTTAGAATCAAGGAATA AAAAACAAATATTATGAACTGCTGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGG TCGAGGCAGGCAGATCACTTAAGGTCAGGAGTTCGAGACCAGCCTGGCCGCCATGGAGAAACCCAGTCT CTACCAAAAATTCAAAAATTAGCCGGGCGTGGTGGCAGGCGCCTGTAATTCCAGGAGGCTGAGGCACAA GAATCGCTTGAACCCAGGCAGCAGAGGTTGCAGTGACCTGAGGTCACACCATTGCACTCCTGCCTGGGC AACAGAATGAGACTCTGTCTCAAAAAAAAAAAACAAAAAAAAAAAAACTACTTCTAATTAGCTCAATAT TAATATTTTAACAAGTTGGGTTGGTAACAGTATATCTTTGCCCATGCTGGCAAATTCTTGTTTTGTCAG CATTTTCCATAACTCTGGCCAAAGTGTCACCTGATGTGGCAACGTTTTACAGTCTTGCTATTGTTTCTT GAGTCCTTTAATCTATAAGATGTATTTTTAAAAATATATAACATATAAATTTTGTTTCGTTATAGCTCT TTAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004756.5
Synonyms	CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23
Summary	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.[UniProtKB/Swiss-Prot Function]
Locus ID	9253
MW	59.9

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.