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Psen1 (NM_008943) Mouse Untagged Clone
CAT＃: MC203369
Psen1 (untagged) - Mouse presenilin 1 (Psen1), (10ug)
CNY 3,656.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Ad3h; PS-1; PS1; S182 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC071233
CCCACGCGTCCGCGGACGCGTGGGTCGCGAGTATTCGTCGGAAACAAAACAGCGGCAGCTGAGGCGGAAA CCTAGGCTGCGAGCCGGCCGCCCGGGCGCGGAGAGAGAAGGAACCAACACAAGACAGCAGCCCTTCGAGG TCTTTAGGCAGCTTGGAGGAGAACACATGAGAGAAAGAATCCCAAGAGGTTTTGTTTTCTTTGAGAAGGT ATTTCTGTCCAGCTGCTCCAATGACAGAGATACCTGCACCTTTGTCCTACTTCCAGAATGCCCAGATGTC TGAGGACAGCCACTCCAGCAGCGCCATCCGGAGCCAGAATGACAGCCAAGAACGGCAGCAGCAGCATGAC AGGCAGAGACTTGACAACCCTGAGCCAATATCTAATGGGCGGCCCCAGAGTAACTCAAGACAGGTGGTGG AACAAGATGAGGAGGAAGACGAAGAGCTGACATTGAAATATGGAGCCAAGCATGTCATCATGCTCTTTGT CCCCGTGACCCTCTGCATGGTCGTCGTCGTGGCCACCATCAAATCAGTCAGCTTCTATACCCGGAAGGAC GGTCAGCTAATCTACACCCCATTCACAGAAGACACTGAGACTGTAGGCCAAAGAGCCCTGCACTCGATCC TGAATGCGGCCATCATGATCAGTGTCATTGTCATTATGACCATCCTCCTGGTGGTCCTGTATAAATACAG GTGCTACAAGGTCATCCACGCCTGGCTTATTATTTCATCTCTGTTGTTGCTGTTCTTTTTTTCGTTCATT TACTTAGGGGAAGTATTTAAGACCTACAATGTCGCCGTGGACTACGTTACAGTAGCACTCCTAATCTGGA ATTTTGGTGTGGTCGGGATGATTGCCATCCACTGGAAAGGCCCCCTTCGACTGCAGCAGGCGTATCTCAT TATGATCAGTGCCCTCATGGCCCTGGTATTTATCAAGTACCTCCCCGAATGGACCGCATGGCTCATCTTG GCTGTGATTTCAGTATATGATTTGGTGGCTGTTTTATGTCCCAAAGGCCCACTTCGTATGCTGGTTGAAA CAGCTCAGGAAAGAAATGAGACTCTCTTTCCAGCTCTTATCTATTCCTCAACAATGGTGTGGTTGGTGAA TATGGCTGAAGGAGACCCAGAAGCCCAAAGGAGGGTACCCAAGAACCCCAAGTATAACACACAAAGAGCG GAGAGAGAGACACAGGACAGTGGTTCTGGGAACGATGATGGTGGCTTCAGTGAGGAGTGGGAGGCCCAAA GAGACAGTCACCTGGGGCCTCATCGCTCCACTCCCGAGTCAAGAGCTGCTGTCCAGGAACTTTCTGGGAG CATTCTAACGAGTGAAGACCCGGAGGAAAGAGGAGTAAAACTTGGACTGGGAGATTTCATTTTCTACAGT GTTCTGGTTGGTAAGGCCTCAGCAACCGCCAGTGGAGACTGGAACACAACCATAGCCTGCTTTGTAGCCA TACTGATCGGCCTGTGCCTTACATTACTCCTGCTCGCCATTTTCAAGAAAGCGTTGCCAGCCCTCCCCAT CTCCATCACCTTCGGGCTCGTGTTCTACTTCGCCACGGATTACCTTGTGCAGCCCTTCATGGACCAACTT GCATTCCATCAGTTTTATATCTAGCCTTTCTGCAGTTAGAACATGGATGTTTCTTCTTTGATTATCAAAA ACACAAAAACAGAGAGCAAGCCCGAGGAGGAGACTGGTGACTTTCCTGTGTCCTCAGCTAACAAAGGCAG GACTCCAGCTGGACTTCTGCAGCTTCCTTCCGAGTCTCCCTAGCCACCCGCACTACTGGACTGTGGAAGG AAGCGTCTACAGAGAACGGTTTCCAACATCCATCGCTGCAGCAGACGGTGTCCCTCAGTGACTTGAGAGA CAAGGACAAGGAAATGTGCTGGGCCAAGGAGCTGCCGTGCTCTGCTAGCTTTGACCCGTGGGCATGGAGA TTTACCCGCACTGTGAACTCTCTAAAGGTTAAACAAAGTGAGGTGAACCAAACAGAGCTGCCATCTTCCA CACCATGTTGGAAATAAAACACGTCCTAGCTGAACCCTTACTGTCCAGGAGGTTCCGTGTGGAGGTGGCA CTGGGCCGGGCCTCCCTCTCAGGCTCTTTTGCTGCCCACTTGTAAGTTTAAATAAGGACACCGCCCTACA CAAACCTCACCCCTGTCACATCAGTGACTCTGACCACTTTTGTTCTCAAACTCTCTCACTATTATCTGTG GTTGCCGTTTCTTCCCAAGGCCAGCCTGGACGAATTTGGGGTTGCTCTATCCTGAGAGTTGTAACCTCAA CTTCCAAAGTTTATATTTTCTTGAAATGATGGATCTATTGCTCAACAGTCCCTGTCATCCTTAAGTGACT TCTGGGTTTCCCACAAATTCCTCACTTTTAGACACACTCTAAGCTTACTTCTGGCCTGGATGCTTCCTCT CCCTGTCTCTCCCTTGCCCCACAGCGGTTCCCTGACAGCAGACAAGGCAGCTCTGGGAGGTAGCTAGTAT CCAATAACCCAGGGGTTTCCTCATGTGATGCAAATACTACGTGTCCAACCAATCAGTGCTGTCAACGGGC TGCCATAGCTCCTTCGATGGCAAATAGGATGTGTGCCCAAAGAATTAAAGCGATGAGTGGCTGGTGAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_008943 |
| Insert Size | 1404 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC071233, AAH71233 |
| RefSeq Size | 2750 bp |
| RefSeq ORF | 1404 bp |
| Locus ID | 19164 |
| UniProt ID | P49769 |
| Gene Summary | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity (By similarity). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10421573, PubMed:11517342). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11226248). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11226248). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (PubMed:9160754, PubMed:10421573, PubMed:12834865). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (PubMed:30429473).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens
,Azimi, M;Le, TT;Brown, NL;,
Differentiation
,PubMed ID 30059908
[PSEN1]
|
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG207460 | Psen1 (tGFP-tagged) - Mouse presenilin 1 (Psen1) |
CNY 3,710.00 |
|
| MR207460 | Psen1 (Myc-DDK-tagged) - Mouse presenilin 1 (Psen1) |
CNY 3,656.00 |
|
| MR207460L3 | Lenti ORF clone of Psen1 (Myc-DDK-tagged) - Mouse presenilin 1 (Psen1) |
CNY 5,230.00 |
|
| MR207460L4 | Lenti ORF clone of Psen1 (mGFP-tagged) - Mouse presenilin 1 (Psen1) |
CNY 5,230.00 |
