Lag3 (NM_008479) Mouse Tagged ORF Clone
CAT#: MG222979
- TrueORF®
Lag3 (tGFP-tagged) - Mouse lymphocyte-activation gene 3 (Lag3), (10ug)
ORF Plasmid: DDK
"NM_008479" in other vectors (4)
Need custom modification / cloning service?
Get a free quote
CNY 5,480.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | TurboGFP |
Synonyms | CD223; LAG-3; Ly66 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MG222979 representing NM_008479
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAGGGAGGACCTGCTCCTTGGCTTTTTGCTTCTGGGACTGCTTTGGGAAGCTCCAGTTGTGTCTTCAG GGCCTGGGAAAGAGCTCCCCGTGGTGTGGGCCCAGGAGGGAGCTCCCGTCCATCTTCCCTGCAGCCTCAA ATCCCCCAACCTGGATCCTAACTTTCTACGAAGAGGAGGGGTTATCTGGCAACATCAACCAGACAGTGGC CAACCCACTCCCATCCCGGCCCTTGACCTTCACCAGGGGATGCCCTCGCCTAGACAACCCGCACCCGGTC GCTACACGGTGCTGAGCGTGGCTCCAGGAGGCCTGCGCAGCGGGAGGCAGCCCCTGCATCCCCACGTGCA GCTGGAGGAGCGCGGCCTCCAGCGCGGGGACTTCTCTCTGTGGTTGCGCCCAGCTCTGCGCACCGATGCG GGCGAGTACCACGCCACCGTGCGCCTCCCGAACCGCGCCCTCTCCTGCAGTCTCCGCCTGCGCGTCGGCC AGGCCTCGATGATTGCTAGTCCCTCAGGAGTCCTCAAGCTGTCTGATTGGGTCCTTTTGAACTGCTCCTT CAGCCGTCCTGACCGCCCAGTCTCTGTGCACTGGTTCCAGGGCCAGAACCGAGTGCCTGTCTACAACTCA CCGCGTCATTTTTTAGCTGAAACTTTCCTGTTACTGCCCCAAGTCAGCCCCCTGGACTCTGGGACCTGGG GCTGTGTCCTCACCTACAGAGATGGCTTCAATGTCTCCATCACGTACAACCTCAAGGTTCTGGGTCTGGA GCCCGTAGCCCCTCTGACAGTGTACGCTGCTGAAGGTTCTAGGGTGGAGCTGCCCTGTCATTTGCCCCCA GGAGTGGGGACCCCTTCTTTGCTCATTGCCAAGTGGACTCCTCCTGGAGGAGGTCCTGAGCTCCCCGTGG CTGGAAAGAGTGGCAATTTTACCCTTCACCTTGAGGCTGTGGGTCTGGCACAGGCTGGGACCTACACCTG TAGCATCCATCTGCAGGGACAGCAGCTCAATGCCACTGTCACGTTGGCGGTCATCACAGTGACTCCCAAA TCCTTCGGGTTACCTGGCTCCCGGGGGAAGCTGTTGTGTGAGGTAACCCCGGCATCTGGAAAGGAAAGAT TTGTGTGGCGTCCCCTGAACAATCTGTCCAGGAGTTGCCCGGGCCCTGTGCTGGAGATTCAGGAGGCCAG GCTCCTTGCTGAGCGATGGCAGTGTCAGCTGTACGAGGGCCAGAGGCTTCTTGGAGCGACAGTGTACGCC GCAGAGTCTAGCTCAGGCGCCCACAGTGCTAGGAGAATCTCAGGTGACCTTAAAGGAGGCCATCTCGTTC TCGTTCTCATCCTTGGTGCCCTCTCCCTGTTCCTTTTGGTGGCCGGGGCCTTTGGCTTTCACTGGTGGAG AAAACAGTTGCTACTGAGAAGATTTTCTGCCTTAGAACATGGGATTCAGCCATTTCCGGCTCAGAGGAAG ATAGAGGAGCTGGAGCGAGAACTGGAGACGGAGATGGGACAGGAGCCGGAGCCCGAGCCGGAGCCACAGC TGGAGCCAGAGCCCAGGCAGCTC ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG222979 representing NM_008479
Red=Cloning site Green=Tags(s) MREDLLLGFLLLGLLWEAPVVSSGPGKELPVVWAQEGAPVHLPCSLKSPNLDPNFLRRGGVIWQHQPDSG QPTPIPALDLHQGMPSPRQPAPGRYTVLSVAPGGLRSGRQPLHPHVQLEERGLQRGDFSLWLRPALRTDA GEYHATVRLPNRALSCSLRLRVGQASMIASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVPVYNS PRHFLAETFLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVLGLEPVAPLTVYAAEGSRVELPCHLPP GVGTPSLLIAKWTPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQQLNATVTLAVITVTPK SFGLPGSRGKLLCEVTPASGKERFVWRPLNNLSRSCPGPVLEIQEARLLAERWQCQLYEGQRLLGATVYA AESSSGAHSARRISGDLKGGHLVLVLILGALSLFLLVAGAFGFHWWRKQLLLRRFSALEHGIQPFPAQRK IEELERELETEMGQEPEPEPEPQLEPEPRQL TRTRPLE - GFP Tag - V |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_008479 |
ORF Size | 1563 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_008479.2, NP_032505.1 |
RefSeq Size | 2020 bp |
RefSeq ORF | 1566 bp |
Locus ID | 16768 |
UniProt ID | Q61790 |
Gene Summary | Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887, PubMed:30580966). Delivers inhibitory signals upon binding to ligands, such as FGL1 (PubMed:30580966). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (PubMed:21300912). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (PubMed:15485628). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (PubMed:19201841). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:12209638, PubMed:12421911, PubMed:15634887).[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC217427 | Lag3 (untagged) - Mouse lymphocyte-activation gene 3 (Lag3), (10ug) |
CNY 1,200.00 |
|
MR222979 | Lag3 (Myc-DDK-tagged) - Mouse lymphocyte-activation gene 3 (Lag3) |
CNY 3,880.00 |
|
MR222979L3 | Lenti ORF clone of Lag3 (Myc-DDK-tagged) - Mouse lymphocyte-activation gene 3 (Lag3) |
CNY 6,280.00 |
|
MR222979L4 | Lenti ORF clone of Lag3 (mGFP-tagged) - Mouse lymphocyte-activation gene 3 (Lag3) |
CNY 6,280.00 |