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EXOSC10 (NM_002685) Human Untagged Clone
CAT＃: SC118513
EXOSC10 (untagged)-Human exosome component 10 (EXOSC10), transcript variant 2
CNY 6,304.00
货期*
现货
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118513 sequence for NM_002685 edited (data generated by NextGen Sequencing)
ATGGCGCCACCCAGTACCCGGGAGCCCAGGGTCCTGTCGGCGACCAGCGCAACCAAATCC GACGGAGAGATGGTGCTGCCAGGCTTCCCGGACGCCGACAGCTTTGTGAAGTTTGCTCTT GGGTCCGTGGTGGCAGTCACCAAGGCATCTGGGGGCCTACCACAGTTTGGCGATGAGTAT GATTTTTACCGAAGTTTTCCTGGCTTCCAAGCATTTTGCGAAACACAGGGAGACAGGTTG CTTCAGTGCATGAGCAGAGTAATGCAGTACCATGGGTGTCGCAGCAACATTAAGGATCGA AGTAAAGTGACTGAGCTGGAAGACAAGTTTGATTTACTAGTTGATGCCAATGATGTAATT CTGGAGAGAGTGGGTATTTTACTGGATGAAGCCTCAGGTGTAAACAAGAATCAACAGCCT GTCCTCCCTGCCGGCTTGCAGGTCCCCAAAACGGTAGTGTCCAGCTGGAACCGTAAGGCA GCAGAATATGGCAAAAAAGCAAAATCTGAAACTTTCCGGCTGCTTCATGCAAAAAATATC ATCCGACCTCAGCTCAAGTTTCGAGAGAAGATTGACAATTCCAACACACCATTTCTTCCT AAAATCTTCATCAAACCCAATGCTCAGAAACCTCTCCCTCAAGCTCTCTCTAAGGAAAGG CGGGAACGCCCACAGGATCGTCCTGAGGACTTGGACGTCCCCCCTGCACTGGCTGATTTC ATCCATCAGCAGAGAACCCAGCAGGTTGAGCAAGACATGTTTGCACATCCTTATCAATAT GAACTAAATCACTTTACCCCAGCAGATGCAGTGCTTCAAAAGCCACAACCCCAGTTATAC AGACCTATAGAAGAGACACCATGCCATTTCATATCCTCCCTGGATGAACTCGTGGAACTC AACGAAAAGCTCTTGAATTGTCAGGAATTTGCAGTTGACTTGGAGCACCACTCTTACAGG AGCTTCCTGGGACTGACCTGCCTGATGCAAATTTCTACTCGGACGGAAGACTTCATCATT GACACCCTCGAGCTTCGAAGTGACATGTACATTCTCAATGAGAGCCTCACAGACCCAGCC ATCGTTAAGGTCTTTCATGGTGCTGATTCAGACATAGAATGGCTACAGAAAGACTTTGGG TTGTATGTAGTAAACATGTTTGATACTCATCAGGCAGCACGCCTTCTTAACCTGGGCAGG CACTCACTCGATCATCTCCTGAAACTCTACTGCAACGTGGACTCAAACAAGCAATATCAG CTGGCTGATTGGAGAATACGCCCTCTGCCCGAGGAGATGCTCAGCTACGCCCGGGATGAC ACCCATTACCTGCTATATATCTATGACAAAATGAGGCTGGAGATGTGGGAGCGCGGCAAC GGGCAGCCCGTGCAGCTGCAGGTGGTGTGGCAACGGAGCAGGGACATCTGCCTCAAGAAA TTCATCAAACCTATCTTCACGGATGAGTCCTACCTTGAACTCTATAGGAAGCAGAAGAAG CACCTTAACACACAGCAGTTGACAGCCTTTCAGCTGCTGTTTGCCTGGAGGGATAAAACA GCTCGCAGGGAAGATGAAAGTTACGGATATGTACTGCCAAACCACATGATGCTGAAAATA GCTGAAGAACTGCCTAAGGAACCTCAGGGCATCATAGCTTGCTGCAACCCAGTACCGCCC CTTGTGCGGCAGCAGATCAACGAAATGCACCTTTTAATCCAGCAGGCCCGAGAGATGCCC CTGCTCAAGTCTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAG AGATTGGAGAATGTTCTCTTTGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTAT CCAATCATCCCAACCAGTGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGAT GAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTA TTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAA GCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGNTCAGCAACCGTTGGAAG CTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAG CAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATC TCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGC GACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCA AAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTC AAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAG ACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAA AGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGA TAG Clone variation with respect to NM_002685.2 1389 g=>c;2083 a=>n;2094 c=>t >OriGene 5' read for NM_002685 unedited
GTAATACGACTCACTTATAGGGCGGCCGCGATTCGGCACGAGGTGAAAAATGGCGCCACC CAGTACCCGGGAGCCCAGGGTCCTGTCGGCGACCAGCGCAACCAAATCCGACGGAGAGAT GGTGCTGCCAGGCTTCCCGGACGCCGACAGCTTTGTGAAGTTTGCTCTTGGGTCCGTGGT GGCAGTCACCAAGGCATCTGGGGGCCTACCACAGTTTGGCGATGAGTATGATTTTTACCG AAGTTTTCCTGGCTTCCAAGCATTTTGCGAAACACAGGGAGACAGGTTGCTTCAGTGCAT GAGCAGAGTAATGCAGTACCATGGGTGTCGCAGCAACATTAAGGATCGAAGTAAAGTGAC TGAGCTGGAAGACAAGTTTGATTTACTAGTTGATGCCAATGATGTAATTCTGGAGAGAGT GGGTATTTTACTGGATGAAGCCTCAGGTGTAAACAAGAATCAACAGCCTGTCCTCCCTGC CGGCTTGCAGGTCCCCAAAACGGTAGTGTCCAGCTGGAACCGTAAGGCAGCAGAATATGG CAAAAAAGCAAAATCTGAAACTTTCCGGCTGCTTCATGCAAAAAATATCATCCGACCTCA GCTCAAGTTTCGAGAGAAGATTGACAATTCCAACACACCATTTCTTCCTAAAATCTTCAT CAAACCCAATGCTCAGAAACCTCTCCCTCAAGCTCTCTCTAAGGAAGGCGGGAACGCCCA CAGGATCGTCCTGAGACTTGGACGTCCCCCCTGCACTGGCTGATTTCATCCATCAGCAGA GAACCCAGCANGTTGAGCAAGAACATGTTGCACATNCCTATCAATATGAACTANATCACC TTTACCCCAGCAGATGCAGTGCTTCAAAAGCCACACCCNCAGTATACAGACTATAGAAGA GACACATGCCATTTCTNATCCTNCCTGGATGGACTCGTGGGACTCACC >OriGene 3' read for NM_002685 unedited
CCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TCTTCAGAAAAAATTTTAATGGTTTAAAAATATGTTTGTACAAAAGCAGCACCAGCTTTT GGGGCTTCCGGTCCACAGGCGCCACGTGTTTTCCAGGACTATTTTTGGGGCCAGTTGTAC CTGAAGCCTTTGTCTGACTTTCCAGTTGGAAAGGACATGCTTTTGTTTCCCACCGACTGT TTAATTTTTTTGGCTGCAATGCATTTTTTGCCAAACGGGGTCTGTTTATTTGGATCAAAC TGAAAAAAAACTTTGGATTTGCTGTTTCCAGCAAAAGCCTTGAAGTCTGACTGGCTGTAG TCGTAAGGCGTAAACTCTTTTTCTGGGGGCTCTGGGTCCTTTGGCTTCTTGGAAATTTTG AGTCGTTTCTTCTCTTGTTTCTGTTCTGGGGCCCTTGGGTCGCTTGTTGCTCGCTCTCTC TTCTTTGCAGCATTTTCTAACACGACCTGCTGTCGGACGGAAATGGCCTGTTCTGCTGCA GCTTTGCACGCCTCCTTTGCCTGTTCCCGGGCAGCTGTTTGCTCAACTGCCTTCTTCTTG ACAGCTTCTTTAGAGCCTTTTTGCCCTTGCACCTGGGCCAACTTCCAACGGTTGCTGATT TCATAAAATTTGGTGGATGGATCCAACCTTCCTGCCTGAAAACGGAAGCCCGGTGGCCCA ATGAGGGCAAAAACCTCCTTAAAGGGTTTTTAAAGGACCCCATGATGTTCTCGGGTTTTT TTTCGGGCACCTGGAAAGGGACCCTTTTTACTGTTTTAACACTTAGGCCATTAAAAAACC GGAAGACCAGCGGGGCAATAGAGCTGGGGGCCCCAACCAGTTATTTCTTTTTAACGGGAA AAGGTCCCCTTCTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002685 |
| Insert Size | 2880 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002685.2, NP_002676.1 |
| RefSeq Size | 2759 bp |
| RefSeq ORF | 2583 bp |
| Locus ID | 5394 |
| UniProt ID | Q01780 |
| Domains | HRDC, 3_5_exonuclease |
| Protein Pathways | RNA degradation |
| Gene Summary | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213555 | EXOSC10 (Myc-DDK-tagged)-Human exosome component 10 (EXOSC10), transcript variant 2 |
CNY 9,120.00 |
|
| RC213555L3 | Lenti-ORF clone of EXOSC10 (Myc-DDK-tagged)-Human exosome component 10 (EXOSC10), transcript variant 2 |
CNY 11,020.00 |
|
| RC213555L4 | Lenti-ORF clone of EXOSC10 (mGFP-tagged)-Human exosome component 10 (EXOSC10), transcript variant 2 |
CNY 11,020.00 |
|
| RG213555 | EXOSC10 (tGFP-tagged) - Human exosome component 10 (EXOSC10), transcript variant 2 |
CNY 10,070.00 |
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