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Arg 3.1 (ARC) (NM_015193) Human Untagged Clone
CAT＃: SC320397
ARC (untagged)-Human activity-regulated cytoskeleton-associated protein (ARC)
CNY 3,656.00
CNY 7,220.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | Arg3.1; hArc |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_015193.3
AATTCGGGCACGAGGGTCCTCCCTCCGCAGCAGCCGAGCCGGACCTGCCTCCCCGGGCGT
GCTCCGCCGGCCCCGCCGCCGGCCCGCAGCGACAGACAGGCGCTCCCCGCAGCTCCGCAC GGGACCCAGGCCGCCGGACCCCAGCGCCGGACCACCCTCTGTCCGCCCCGAGGAGTTTGC CGCCTGCCGGAGCACCTGCGCACAGATGGAGCTGGACCACCGGACCAGCGGCGGGCTCCA CGCCTACCCCGGGCCGCGGGGCGGGCAGGTGGCCAAGCCCAACGTGATCCTGCAGATCGG GAAGTGCCGGGCCGAGATGCTGGAGCACGTGCGGCGGACGCACCGGCACCTGCTGGCCGA GGTGTCCAAGCAGGTGGAGCGCGAGCTGAAGGGGCTGCACCGGTCGGTCGGGAAGCTGGA GAGCAACCTGGACGGCTACGTGCCCACGAGCGACTCGCAGCGCTGGAAGAAGTCCATCAA GGCCTGCCTGTGCCGCTGCCAGGAGACCATCGCCAACCTGGAGCGCTGGGTCAAGCGCGA GATGCACGTGTGGCGCGAGGTGTTCTACCGCCTGGAGCGCTGGGCCGACCGCCTGGAGTC CACGGGCGGCAAGTACCCGGTGGGCAGCGAGTCAGCCCGCCACACCGTTTCCGTGGGCGT GGGGGGTCCCGAGAGCTACTGCCACGAGGCAGACGGCTACGACTACACCGTCAGCCCCTA CGCCATCACCCCGCCCCCAGCCGCTGGCGAGCTGCCCGGGCAGGAGCCCGCCGAGGCCCA GCAGTACCAGCCGTGGGTCCCCGGCGAGGACGGGCAGCCCAGCCCCGGCGTGGACACGCA GATCTTCGAGGACCCTCGAGAGTTCCTGAGCCACCTAGAGGAGTACTTGCGGCAGGTGGG CGGCTCTGAGGAGTACTGGCTGTCCCAGATCCAGAATCACATGAACGGGCCGGCCAAGAA GTGGTGGGAGTTCAAGCAGGGCTCCGTGAAGAACTGGGTGGAGTTCAAGAAGGAGTTCCT GCAGTACAGCGAGGGCACGCTGTCCCGAGAGGCCATCCAGCGGGAGCTGGACCTGCCGCA GAAGCAGGGCGAGCCGCTGGACCAGTTCCTGTGGCGCAAGCGGGACCTGTACCAGACGCT CTACGTGGACGCGGACGAGGAGGAGATCATCCAGTACGTGGTGGGCACCCTGCAGCCCAA GCTCAAGCGTTTCCTGCGCCACCCCCTGCCCAAGACCCTGGAGCAGCTCATCCAGAGGGG CATGGAGGTGCAGGATGACCTGGAGCAGGCGGCCGAGCCGGCCGGCCCCCACCTCCCGGT GGAGGATGAGGCGGAGACCCTCACGCCCGCCCCCAACAGCGAGTCCGTGGCCAGTGACCG GACCCAGCCCGAGTAGAGGGCATCCCGGAGCCCCCAGCCTGCCCACTACATCCAGCCTGT GGCTTTGCCCACCAGGACTTTTGAGCTGGGGCTGACTCCTGCAGGGGAAGCCCTGGTCCA GCTGGGTGCCCCCTCGAGCTCCGGGCGGACTCGCACACACTCGTGTCATCCAGATGTGAG CACCGCACCCAGCGGCAAAGAGCCCTCCCCCCTGCAGGGCTCCACCCATCACCCTCCCTC CGTCTGTCTTTCCGGCCTGGACCCCACCCTCCACACTCTCAGGCCATCACAGAACACCCC AGCTTCCTCATTCTGCTACAACACCCAGGCCCTCTGGACATCCAGAAAACCAAGTGTCCG GATGGCAGGGGCCAGCGGCCACCAAGCTCATGGGACACCCAGAGCAGAAGCTAGGGCAGA GCCAATGCTGAGGGAGCCTCGACTTCCGGCGCCGCCGCCCTCTCCCGGCATCCGCAGAGC CAGCTGACGCCCTCCCTGCCTCCCAGGGCAGCTGGCCAGCCTCGGGCAGCGCGGCCCCCT CCTCCCAGGGGAGAGTAGAAGTCGCACACGCAGCAGAGCAGACCTGATGTCCCGGTGCTT CCTGGCCCCTCAGCTCCAGTGATTCACGCCCGCCTGGAGAAGAATCAGAGCTCAGCTCAT GACTCACCCATGGCAGGCGGAGGGTCCCAGAGGGGCTGAGTCCTCAAATCCGGCTGAGGC AGCAGCTGGCACCATCAGAGCCAGGAGAGTGACAACAGGTCTCAAGGTTCCCACAAAGTC TTTGCTGCTGTGCTGGGCACCACCCACCCCTCACCTTGCAGGCTGCCTGCGTGGGAGGCG AAGTCCCAGGACAGCCCAGAGGGGGGCTACAGAGAGGAGTCGGCTGCAGCAGAGGGCAGG AGCCCCAGCTTAGCCCTGAGCGCCAGCGCGAGGACCAGGGCCTGCCACTAAGCCCGCCCC GCTGGCCGCCAGCTGCCCGTCCCCAGAGCCACTGCAGCAGGAGTCGGGCCCTGCCTCCCT CCCAGCAGGGAAACCCCGCCCGCTGCCAGGCCATCCTCTCTGCCAGAGGCTTTCATGAGC CCCAAGGCTGGGGCCACAGCTCCTACCCCTGCCCAGCAGCCCTGAGCTCAGCTGCAGGAA GGACATCCCAGAAGCCATGGCTCCTGGGGCGCTTCCAGGCATTCTGCCCTGCCCCGACAC CAGAACCCTGGTGCTGGTGGGCCACTAGCGTCTGCAGCCTAAGCAGGTGCTGGCTCAGGG TTCATCGTTCTGCCTTGTCCACTGGGGGACCAGCCCTGCAGACCACTCTGACAAGTCTTC AGCCCACACCCTGCCAGCCCCACAGATTTTATTTTTGCACATAAGCCATAACCAATCCTC AAGGCTGGCACAGGCTTTGGGGAAGCCCTGGAGCCTGTGAAGACCCTGGAAACCTCATGA GGCTGTGGCCAACCCCTGCCCCTTGCCCCACACAGACCAGGCCTTAAATGTCGGTCCAGG CCCTGTGCACCTTACCCCAGAGACAGACTCTTTTTGTAAGATTTTGTTAATAAAACACTG AAACTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_015193 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_015193.3, NP_056008.1 |
| RefSeq Size | 2985 bp |
| RefSeq ORF | 1191 bp |
| Locus ID | 23237 |
| UniProt ID | Q7LC44 |
| Gene Summary | Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204129 | ARC (Myc-DDK-tagged)-Human activity-regulated cytoskeleton-associated protein (ARC) |
CNY 3,656.00 |
|
| RC204129L1 | Lenti-ORF clone of ARC (Myc-DDK-tagged)-Human activity-regulated cytoskeleton-associated protein (ARC) |
CNY 6,056.00 |
|
| RC204129L2 | Lenti-ORF clone of ARC (mGFP-tagged)-Human activity-regulated cytoskeleton-associated protein (ARC) |
CNY 5,890.00 |
|
| RC204129L3 | Lenti-ORF clone of ARC (Myc-DDK-tagged)-Human activity-regulated cytoskeleton-associated protein (ARC) |
CNY 5,890.00 |
|
| RC204129L4 | Lenti-ORF clone of ARC (mGFP-tagged)-Human activity-regulated cytoskeleton-associated protein (ARC) |
CNY 5,890.00 |
|
| RG204129 | ARC (tGFP-tagged) - Human activity-regulated cytoskeleton-associated protein (ARC) |
CNY 5,256.00 |
|
| SC114711 | ARC (untagged)-Human activity-regulated cytoskeleton-associated protein (ARC) |
CNY 3,656.00 |
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