Rnf41 (BC019415) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR201892L4V

  • LentiORF®

Lenti ORF particles, Rnf41 (GFP-tagged) - Mouse ring finger protein 41 (cDNA clone MGC:30902 IMAGE:4014525), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 7,505.00


货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Rnf41 (BC019415) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms 4933415P08Rik, FLRF
Vector pLenti-C-mGFP-P2A-Puro
ACCN BC019415
ORF Size 582 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR201892).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq BC019415, AAH19415
RefSeq Size 1739 bp
RefSeq ORF 584 bp
Locus ID 67588
Gene Summary Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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