SMAD4 (NM_005359) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC201828L3V
- LentiORF®
Lenti ORF particles, SMAD4 (Myc-DDK tagged) - Human SMAD family member 4 (SMAD4), 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
Product Data | |
Product Name | SMAD4 (NM_005359) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | DPC4; JIP; MADH4; MYHRS |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_005359 |
ORF Size | 1656 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC201828).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_005359.3 |
RefSeq Size | 3220 bp |
RefSeq ORF | 1659 bp |
Locus ID | 4089 |
Domains | DWB, DWA, MH1 |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Adherens junction, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway |
MW | 60.3 kDa |
Gene Summary | This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017] |
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