Niemann Pick C1 (NPC1) (NM_000271) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC209258L2V
- LentiORF®
Lenti ORF particles, NPC1 (mGFP-tagged)-Human Niemann-Pick disease, type C1 (NPC1), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 12,540.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
Product Data | |
Product Name | Niemann Pick C1 (NPC1) (NM_000271) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | NPC; POGZ; SLC65A1 |
Vector | pLenti-C-mGFP |
ACCN | NM_000271 |
ORF Size | 3834 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC209258).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_000271.4 |
RefSeq Size | 4827 bp |
RefSeq ORF | 3837 bp |
Locus ID | 4864 |
Domains | Patched |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Lysosome |
MW | 142.1 kDa |
Gene Summary | This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
You may also need
其它Niemann Pick C1产品
Customer
Reviews
Loading...