Human HLA DP (HLA-DPA1) activation kit by CRISPRa
CAT#: GA102125
HLA-DPA1 CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class II, DP alpha 1
CNY 12,255.00
货期*
4周
规格
经常一起买 (2)
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | HLA-DPA1 |
Locus ID | 3113 |
Kit Components | GA102125G1, HLA DP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102125G2, HLA DP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102125G3, HLA DP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001242524, NM_001242525, NM_033554 |
Synonyms | DP(W3); DP(W4); HLA-DP1A; HLADP; HLASB; PLT1 |
Summary | HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008] |
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